『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kato Hiroyuki (日) (読)
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2.荒木 勉
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3. (英) Imai Yutaka (日) (読)
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4. (英) Takahashi Akira (日) (読)
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5. (英) Itoyama Yasuto (日) (読)
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題名 (必須): (英) Ptotection of dopamininergic neurons with a novel astrocyte modulating agent (R)-(-)2-propyloctanoic acid (ONO-2506) in an MPTP-treated mouse model of Parkinson's disease  (日)    [継承]
副題 (任意):
要約 (任意): (英) We examined the neuroprotective effects of a novel astrocyte-modulating agent, (R)-(-)-2-propyloctanoic acid (ONO-2506), in a mouse model of Parkinson's disease. Male C57BL/6 mice received four intraperitoneal injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (10 mg/kg) at 1-h intervals. Dopamine content in the striatum, measured with HPLC 3 days after MPTP injection, was reduced to 23% of control. But this dopamine depletion was dose-dependently prevented by repeated treatments with ONO-2506 (3, 10 and 30 mg/kg, i.p.) administered 1, 6, 24 and 48 h after MPTP injection (51% of control in 30 mg/kg group, p<0.01). ONO-2506 treatment (30 mg/kg) started after 6 h, followed by treatments at 24 and 48 h, also prevented the reduction of dopamine content (42% of control vs. 11% of control in the saline-treated group, p<0.01). We also performed immunohistochemistry for tyrosine hydroxylase (TH) and glial fibrillary acidic protein (GFAP). The MPTP injection resulted in a loss of TH-positive dopaminergic neurons (42% of control, p<0.01) in the substantia nigra after 7 days, but ONO-2506 treatment prevented this neuronal loss (70% of control, p<0.01). The MPTP injection led to reactive astrocytosis in the striatum after 7 days, but ONO-2506 induced earlier, moderate astrocytic activation after 3-7 days. These findings show that ONO-2506 protects dopaminergic neurons against MPTP neurotoxicity probably through facilitating astrocytic support for neuronal recovery from injury. Pharmacological modulation of astrocytes may offer a novel therapeutic strategy for Parkinson's disease.  (日)    [継承]
キーワード (推奨): 1. (英) 3,4-Dihydroxyphenylacetic Acid (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Astrocytes (日) (読) [継承]
4. (英) Corpus Striatum (日) (読) [継承]
5. (英) Disease Models, Animal (日) (読) [継承]
6.ドーパミン (dopamine) [継承]
7. (英) Dose-Response Relationship, Drug (日) (読) [継承]
8. (英) Drug Interactions (日) (読) [継承]
9. (英) Glial Fibrillary Acidic Protein (日) (読) [継承]
10.免疫組織化学 (immunohistochemistry) [継承]
11. (英) Male (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Inbred C57BL (日) (読) [継承]
14. (英) Neuroprotective Agents (日) (読) [継承]
15. (英) Octanoic Acids (日) (読) [継承]
16.パーキンソン病 (Parkinson's disease) [継承]
17. (英) Parkinsonian Disorders (日) (読) [継承]
18. (英) Substantia Nigra (日) (読) [継承]
19. (英) Time Factors (日) (読) [継承]
20. (英) Tyrosine 3-Monooxygenase (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of the Neurological Sciences (World Federation of Neurology)
(pISSN: 0022-510X, eISSN: 1878-5883)

ISSN (任意): 0022-510X
ISSN: 0022-510X (pISSN: 0022-510X, eISSN: 1878-5883)
Title: Journal of the neurological sciences
Title(ISO): J Neurol Sci
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 9 15 [継承]
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年月日 (必須): 西暦 2003年 4月 15日 (平成 15年 4月 15日) [継承]
URL (任意):
DOI (任意): 10.1016/S0022-510X(02)00411-2    (→Scopusで検索) [継承]
PMID (任意): 12639719    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku,Sendai 980-8574, Japan. katoh@mail.cc.tohoku.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hiroyuki Kato, Tsutomu Araki, Yutaka Imai, Akira Takahashi and Yasuto Itoyama : Ptotection of dopamininergic neurons with a novel astrocyte modulating agent (R)-(-)2-propyloctanoic acid (ONO-2506) in an MPTP-treated mouse model of Parkinson's disease, Journal of the Neurological Sciences, Vol.208, No.1-2, 9-15, 2003.
欧文冊子 ● Hiroyuki Kato, Tsutomu Araki, Yutaka Imai, Akira Takahashi and Yasuto Itoyama : Ptotection of dopamininergic neurons with a novel astrocyte modulating agent (R)-(-)2-propyloctanoic acid (ONO-2506) in an MPTP-treated mouse model of Parkinson's disease, Journal of the Neurological Sciences, Vol.208, No.1-2, 9-15, 2003.

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