『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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著者 (必須): 1. (英) Muramatsu Yasuko (日) (読)
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2. (英) Kurosaki Rumiko (日) (読)
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3. (英) Watanabe Hijiri (日) (読)
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4. (英) Michimata Mari (日) (読)
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5. (英) Matsubara Mitsunobu (日) (読)
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6. (英) Imai Yutaka (日) (読)
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7.荒木 勉
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題名 (必須): (英) Expression of S-100 protein is related to neuronal damage in MPTP-treated mice  (日)    [継承]
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要約 (任意): (英) S-100beta is a calcium-binding protein expressed at high levels in brain and is known as a marker of brain damage. However, little is known about the role of S-100beta protein during neuronal damage caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To determine whether S-100beta protein is induced in glial cells after MPTP treatment, we investigated the expression of S-100 protein immunohistochemically, using MPTP-treated mice. We also examined the change of neurons and glial cells in mice after MPTP treatment. The present study shows that tyrosine hydroxylase (TH) immunoreactivity decreased gradually in the striatum and substantia nigra from 1 day after MPTP treatment. Thereafter, TH-immunopositive cells and fibers decreased in the striatum and substantia nigra at 3 days after MPTP treatment. In contrast, S-100-immunopositive cells and glial fibrillary acidic protein (GFAP)-immunopositive cells increased markedly in the striatum and substantia nigra at 3 days after MPTP treatment. Seven days after MPTP treatment, S-100-immunopositive cells decreased in the striatum and substantia nigra. However, the number of GFAP-immunopositive cells increased in these regions. In double-labeled immunostaining with anti-S-100 and anti-GFAP antibodies, S-100 immunoreactivity was observed only in the GFAP-positive astrocytes. These results provide evidence that astrocytic activation may play a role in the pathogenesis of MPTP-induced degeneration of dopaminergic neurons. Furthermore, the present study demonstrates that S-100 protein is expressed selectively by astrocytes, but not by microglia, after MPTP treatment. These results provide valuable information for the pathogenesis of the acute stage of Parkinson's disease.  (日)    [継承]
キーワード (推奨): 1. (英) MPTP (日) (読) [継承]
2.免疫組織化学 (immunohistochemistry) [継承]
3. (英) S-100 (日) (読) [継承]
4. (英) dopaminergic system (日) (読) [継承]
5. (英) astrocytes (日) (読) [継承]
6. (英) mice (日) (読) [継承]
発行所 (推奨): Wiley-Liss, Inc. [継承]
誌名 (必須): Glia ([Wiley Periodicals, Inc.])
(pISSN: 0894-1491, eISSN: 1098-1136)

ISSN (任意): 0894-1491
ISSN: 0894-1491 (pISSN: 0894-1491, eISSN: 1098-1136)
Title: Glia
Title(ISO): Glia
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 42 [継承]
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年月日 (必須): 西暦 2003年 3月 25日 (平成 15年 3月 25日) [継承]
URL (任意): http://www3.interscience.wiley.com/cgi-bin/abstract/104086206/ABSTRACT [継承]
DOI (任意): 10.1002/glia.10225    (→Scopusで検索) [継承]
PMID (任意): 12673835    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yasuko Muramatsu, Rumiko Kurosaki, Hijiri Watanabe, Mari Michimata, Mitsunobu Matsubara, Yutaka Imai and Tsutomu Araki : Expression of S-100 protein is related to neuronal damage in MPTP-treated mice, Glia, Vol.42, No.3, 307-311, 2003.
欧文冊子 ● Yasuko Muramatsu, Rumiko Kurosaki, Hijiri Watanabe, Mari Michimata, Mitsunobu Matsubara, Yutaka Imai and Tsutomu Araki : Expression of S-100 protein is related to neuronal damage in MPTP-treated mice, Glia, Vol.42, No.3, 307-311, 2003.

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