『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=88371)

EID=88371EID:88371, Map:0, LastModified:2012年10月25日(木) 14:41:51, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[吉岡 昌美], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.歯学部.歯学科.基礎口腔科学講座.予防歯学 (予防歯科学講座) [継承]
著者 (必須): 1.吉岡 昌美
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[継承]
2.横山 希実
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3.増田 かなめ ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.予防歯学]/->個人[三木 かなめ])
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[継承]
4. (英) Tomoaki Honna (日) (読)
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[継承]
5.日野出 大輔 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健衛生学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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[継承]
6.中村 亮 ([徳島大学])
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[継承]
7. (英) Mahmoud Rouabhia (日) (読)
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[継承]
8. (英) Denis Mayrand (日) (読)
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[継承]
9. (英) Daniel Grenier (日) (読)
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[継承]
題名 (必須): (英) Effect of hydroxamic acid-based MMP inhibitors on human gingival cells and Porphyromonas gingivalis  (日)    [継承]
副題 (任意):
要約 (任意): (英) Matrix metalloproteinases (MMPs) are considered to play key roles in tissue destruction during periodontitis. In this study, we evaluated the cytotoxicity of hydroxamic acid-based MMP inhibitors (ONO-4817, ONO-MI1-514, and ONO-MI1-570), and their inhibitory effects on MMP-2 and -9 activities and growth of Porphyromonas gingivalis. Human gingival fibroblasts (HGF) and human gingival epithelial cells (HGE) were incubated with test inhibitors prior to investigating cell viability, cell proliferation, and mRNA expression for MMP-2 and -9. Gelatin zymography and a colorimetric MMP assay were performed to study the inhibitory effects on MMP-2 and -9 activities derived from HGF and HGE, respectively. The effect of MMP inhibitors on keratinocyte migration and P. gingivalis growth was also tested. Cell viability was not affected by any of the inhibitors at a final concentration of 50 microM, nor was cell proliferation at 20 microM. All inhibitors clearly inhibited MMP-2 produced by HGF and MMP-9 produced by HGE in a dose-dependent manner. No change was found in mRNA expression of MMPs by gingival cells treated with the inhibitors. ONO-4817 and ONO-MI1-514 inhibited keratinocyte migration. ONO-4817 showed a slightly inhibitory effect on the growth of P. gingivalis. Data obtained in this study support the potential use of the three MMP inhibitors for the prevention and treatment of periodontal disease.  (日)    [継承]
キーワード (推奨): 1. (英) cells (日) (読) [継承]
2. (英) gingival epithelial (日) (読) [継承]
3. (英) cytotoxicity (日) (読) [継承]
4. (英) fibroblasts (日) (読) [継承]
5. (英) gingival (日) (読) [継承]
6. (英) hydroxamic acids (日) (読) [継承]
7. (英) metalloproteinase tissue inhibitors (日) (読) [継承]
8. (英) matrix (日) (読) [継承]
9. (英) metalloproteinases (日) (読) [継承]
10. (英) Porphyromonas gingivalis (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Periodontology (American Academy of Periodontology)
(pISSN: 0022-3492, eISSN: 1943-3670)

ISSN (任意): 0022-3492
ISSN: 0022-3492 (pISSN: 0022-3492, eISSN: 1943-3670)
Title: Journal of periodontology
Title(ISO): J. Periodontol.
Supplier: American Academy of Periodontology
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef  (CrossRef (Scopus information is found. [need login])
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(必須): 74 [継承]
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(必須): 1219 1224 [継承]
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年月日 (必須): 西暦 2003年 8月 初日 (平成 15年 8月 初日) [継承]
URL (任意):
DOI (任意): 10.1902/jop.2003.74.8.1219    (→Scopusで検索) [継承]
PMID (任意): 14514237    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Preventive Dentistry, School of Dentistry, The University of Tokushima, Tokushima, Japan. masami@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Masami Yoshioka, Nozomi Yokoyama, Kaname Masuda, Honna Tomoaki, Daisuke Hinode, Ryo Nakamura, Rouabhia Mahmoud, Mayrand Denis and Grenier Daniel : Effect of hydroxamic acid-based MMP inhibitors on human gingival cells and Porphyromonas gingivalis, Journal of Periodontology, Vol.74, No.8, 1219-1224, 2003.
欧文冊子 ● Masami Yoshioka, Nozomi Yokoyama, Kaname Masuda, Honna Tomoaki, Daisuke Hinode, Ryo Nakamura, Rouabhia Mahmoud, Mayrand Denis and Grenier Daniel : Effect of hydroxamic acid-based MMP inhibitors on human gingival cells and Porphyromonas gingivalis, Journal of Periodontology, Vol.74, No.8, 1219-1224, 2003.

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