| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.歯学部.歯学科.機能維持系臨床歯学講座.歯科保存学 (〜2021年3月31日)
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| ○著者 (必須): | 1. | 細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 2. | 中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.再生歯科治療学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 3. | 山口 大輔
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| 4. | 高橋 加奈子
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| 5. | 湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
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| 6. | 尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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| 7. | 松尾 敬志
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| ○題名 (必須): | □ | (英) Macrophage Inflammatory Protein 3α-CC chemokine receptor 6 interactions play an important role in CD4+ T-cell accumulation in periodontal diseased tissue. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The regulatory role of chemokines and chemokine receptors on specific lymphocyte recruitment into periodontal diseased tissue is poorly characterized. We observed that lymphocytes infiltrating inflamed gingival tissue expressed marked levels of CCR6. In periodontal diseased tissue, the expression of MIP-3alpha mRNA was detected by RT-PCR and further, MIP-3alpha was distributed in the basal layer of gingival epithelial cells, microvascular endothelial cells and the areas of inflammatory cells as shown by immunohistochemistry. Moreover, CCR6-expressing cells infiltrated into periodontal diseased tissue, and the proportion of CCR6-positive CD4+ T cells was significantly elevated in periodontal diseased tissue compared with peripheral blood in the same patients. Furthermore, gingival lymphocytes isolated from patients showed migration toward MIP-3alpha in an in vitro chemotaxis assay in which migration was abrogated by specific antibody to CCR6. Thus, these findings suggested that CCR6 and the corresponding chemokine, MIP-3alpha may have an important regulatory role in specific lymphocyte migration into inflamed periodontal tissue. (日)
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| ○キーワード (推奨): | 1. | (英) CCR6 (日) (読)
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| 2. | (英) MIP-3 alpha (日) (読)
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| 3. | (英) periodontal disease (日) (読)
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| 4. | (英) MONOCYTE CHEMOATTRACTANT PROTEIN-1 (日) (読)
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| 5. | (英) INFLAMED HUMAN GINGIVA (日) (読)
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| 6. | (英) IMMUNOHISTOLOGICAL ANALYSIS (日) (読)
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| 7. | (英) SELECTIVE RECRUITMENT (日) (読)
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| 8. | (英) INDUCIBLE EXPRESSION (日) (読)
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| 9. | (英) BACTERIA (日) (読)
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| 10. | (英) IMMUNITY (日) (読)
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| 11. | (英) HEALTHY (日) (読)
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| 12. | (英) LESIONS (日) (読)
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| 13. | (英) SUBSETS (日) (読)
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| ○発行所 (推奨): | □ | Blackwell Publishing Ltd
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| ○誌名 (必須): | □ | Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)
| ○ISSN (任意): | □ | 0009-9104
ISSN: 0009-9104
(pISSN: 0009-9104, eISSN: 1365-2249) Title: Clinical and experimental immunologyTitle(ISO): Clin Exp ImmunolSupplier: British Society for ImmunologyPublisher: Oxford University Press (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 128
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 548 554
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2002年 6月 初日 (平成 14年 6月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1046/j.1365-2249.2002.01865.x (→Scopusで検索)
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| ○PMID (任意): | □ | 12067311 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) OtherID: PMC1906256 (日)
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