| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.歯学部.歯学科.機能維持系臨床歯学講座.歯科保存学 (〜2021年3月31日)
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| ○著者 (必須): | 1. | 中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.再生歯科治療学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | 清水 洋利 ([岡山大学])
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| ○貢献度 (任意): |
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| 3. | 細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | 松尾 敬志
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| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) An immunohistological study on cyclooxygenase-2 in human dental pulp. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Characteristics of cyclooxygenase-2 (COX-2) expressing cells in human dental pulp were immunohistologically studied. Extirpated pulpal tissues from extracted teeth were examined to elucidate the localization and distribution of COX-2. Pulpal tissues were examined by the labeled streptavidin biotin method using specific mouse monoclonal antibodies for COX-2. Cell types of the COX-2 expressing cells were also investigated by the double stain technique using both monoclonal antibodies for CD68/macrophage and anti-COX-2. COX-2 expressing cells could be found in all of the inflamed pulps, and these cells were mostly distributed close to the area of accumulation of inflammatory cells. COX-2 was mainly expressed in fibroblasts rather than macrophages. In contrast, COX-2 expressing cells were scarcely found in the normal pulps. These findings indicate that pulpal fibroblasts, as well as macrophages, may participate in the production of prostaglandin through COX-2 expression in pulpal inflammation, and might be involved in the pathogenesis of irreversible pulpitis. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Antibodies, Monoclonal (日) (読)
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| 3. | (英) Antigens, CD (日) (読)
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| 4. | (英) Antigens, Differentiation, Myelomonocytic (日) (読)
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| 5. | (英) Coloring Agents (日) (読)
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| 6. | (英) Cyclooxygenase 2 (日) (読)
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| 7. | (英) Dental Pulp (日) (読)
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| 8. | (英) Fibroblasts (日) (読)
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| 9. | (英) Fluorescent Dyes (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Immunoenzyme Techniques (日) (読)
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| 12. | (英) Immunohistochemistry (日) (読)
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| 13. | (英) Isoenzymes (日) (読)
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| 14. | (英) Macrophages (日) (読)
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| 15. | (英) Membrane Proteins (日) (読)
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| 16. | (英) Middle Aged (日) (読)
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| 17. | (英) Peroxidases (日) (読)
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| 18. | (英) Prostaglandin-Endoperoxide Synthases (日) (読)
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| 19. | (英) Prostaglandins (日) (読)
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| 20. | (英) Pulpitis (日) (読)
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| ○発行所 (推奨): | □ | The American Association of Endodontics
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| ○誌名 (必須): | □ | Journal of Endodontics ([The American Association of Endodontics])
(pISSN: 0099-2399, eISSN: 1878-3554)
| ○ISSN (任意): | □ | 0099-2399
ISSN: 0099-2399
(pISSN: 0099-2399, eISSN: 1878-3554) Title: Journal of endodonticsTitle(ISO): J EndodPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 27
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 385 388
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2001年 6月 初日 (平成 13年 6月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1097/00004770-200106000-00003 (→Scopusで検索)
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| ○PMID (任意): | □ | 11487130 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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