『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.ゲノム機能研究センター (〜2008年3月31日/->組織[徳島大学.疾患プロテオゲノム研究センター]) [継承]
著者 (必須): 1.Nasreen Mariam
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貢献度 (任意):
学籍番号 (推奨):
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2.上野 智雄
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3. (英) Saito Fumi (日) (読)
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4.高浜 洋介
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題名 (必須): (英) In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla.  (日)    [継承]
副題 (任意):
要約 (任意): (英) TCR ligation by the self-peptide-associated MHC molecules is essential for T cell development in the thymus, so that class II MHC-deficient mice do not generate CD4(+)CD8(-) T cells. The present results show that the administration of anti-TCR mAb into class II MHC-deficient mice restores the generation of CD4(+)CD8(-) T cells in vivo. The CD4 T cells were recovered in the thymus, peripheral blood, and the spleen, indicating that the anti-TCR treatment is sufficient for peripheral supply of newly generated CD4 T cells. Unlike peripheral CD4 T cells that disappeared within 5 wk after the treatment, CD4(+)CD8(-) thymocytes remained undiminished even after 5 wk, suggesting that CD4 T cells in the thymus are maintained separately from circulating CD4 T cells and even without class II MHC molecules. It was also found that the mass of medullary region in the thymus, which was reduced in class II MHC-deficient mice, was restored by the anti-TCR administration, suggesting that the medulla for CD4(+)CD8(-) thymocytes is formed independently of the medulla for CD4(-)CD8(+) thymocytes. These results indicate that in vivo anti-TCR treatment in class II MHC-deficient mice restores the generation of circulating CD4 T cells and optimal formation of the medulla in the thymus, suggesting that anti-TCR Ab may be useful for clinical treatment of class II MHC deficiencies.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Animals, Newborn (日) (読) [継承]
3. (英) Antibodies, Monoclonal (日) (読) [継承]
4. (英) Antigens, CD4 (日) (読) [継承]
5. (英) Antigens, CD8 (日) (読) [継承]
6. (英) CD4-CD8 Ratio (日) (読) [継承]
7. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
8.細胞分化 (cell differentiation) [継承]
9.細胞分裂 (cell division) [継承]
10. (英) Fetus (日) (読) [継承]
11. (英) Genes, T-Cell Receptor beta (日) (読) [継承]
12. (英) Histocompatibility Antigens Class II (日) (読) [継承]
13. (英) Hybridomas (日) (読) [継承]
14. (英) Injections, Intraperitoneal (日) (読) [継承]
15. (英) Lymphocyte Activation (日) (読) [継承]
16. (英) Mice (日) (読) [継承]
17. (英) Mice, Inbred C57BL (日) (読) [継承]
18.ノックアウトマウス (knockout mice) [継承]
19. (英) Organ Culture Techniques (日) (読) [継承]
20. (英) T-Lymphocyte Subsets (日) (読) [継承]
21. (英) Thymus Gland (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 171 [継承]
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(必須): 3394 3400 [継承]
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年月日 (必須): 西暦 2003年 10月 1日 (平成 15年 10月 1日) [継承]
URL (任意): http://www.jimmunol.org/cgi/content/abstract/171/7/3394 [継承]
DOI (任意):
PMID (任意): 14500633    (→Scopusで検索) [継承]
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WOS (任意): 000185548000012 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Mariam Nasreen, Tomoo Ueno, Fumi Saito and Yousuke Takahama : In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla., The Journal of Immunology, Vol.171, No.7, 3394-3400, 2003.
欧文冊子 ● Mariam Nasreen, Tomoo Ueno, Fumi Saito and Yousuke Takahama : In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla., The Journal of Immunology, Vol.171, No.7, 3394-3400, 2003.

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