『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=84825EID:84825, Map:0, LastModified:2018年12月3日(月) 14:24:16, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[高浜 洋介], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.ゲノム機能研究センター (〜2008年3月31日/->組織[徳島大学.疾患プロテオゲノム研究センター]) [継承]
著者 (必須): 1.高浜 洋介
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Nakauchi Hiromitsu (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Positive selection of immature thymocytes is a developmental process in which TCR ligation by low avidity interaction induces the generation of mature T cells. However, biochemical signals that can induce positive selection have been unclear. By using TCR-alpha beta- mutant thymus cultures, the present study shows that direct stimulation of intracellular signals by PMA and calcium ionophore ionomycin can induce the generation of mature CD4+8- T cells, bypassing TCR-induced positive selection signals. Interestingly, the concentrations of phorbol ester that induced positive selection were more restricted than those that induced mature T cell activation. Moreover, the combination of phorbol ester and ionomycin restored the generation of CD4+8- T cells in class II MHC- thymus cultures, but did not induce the generation of CD4-8+ T cells in class I MHC- thymus cultures. These results identify that the combination of protein kinase C activation and calcium elevation is the biochemical signal that can induce positive selection of CD4+ T cells.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Animals, Newborn (日) (読) [継承]
3. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
4. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
5. (英) Cells, Cultured (日) (読) [継承]
6. (英) Clonal Deletion (日) (読) [継承]
7. (英) Enzyme Activation (日) (読) [継承]
8. (英) Histocompatibility Antigens Class I (日) (読) [継承]
9. (英) Histocompatibility Antigens Class II (日) (読) [継承]
10. (英) Ionomycin (日) (読) [継承]
11. (英) Ionophores (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Knockout (日) (読) [継承]
14. (英) Protein Kinase C (日) (読) [継承]
15. (英) Receptors, Antigen, T-Cell (日) (読) [継承]
16. (英) Receptors, Antigen, T-Cell, alpha-beta (日) (読) [継承]
17. (英) Signal Transduction (日) (読) [継承]
18. (英) Tetradecanoylphorbol Acetate (日) (読) [継承]
19. (英) Thymus Gland (日) (読) [継承]
発行所 (推奨): The American Association of Immunologists [継承]
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 157 [継承]
(必須): 4 [継承]
(必須): 1508 1513 [継承]
都市 (任意):
年月日 (必須): 西暦 1996年 8月 15日 (平成 8年 8月 15日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8759732&dopt=Abstract [継承]
DOI (任意):
PMID (任意): 8759732    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yousuke Takahama and Hiromitsu Nakauchi : Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells., The Journal of Immunology, Vol.157, No.4, 1508-1513, 1996.
欧文冊子 ● Yousuke Takahama and Hiromitsu Nakauchi : Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells., The Journal of Immunology, Vol.157, No.4, 1508-1513, 1996.

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