| ○種別 (必須): | □ | 総説·解説
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.薬学部.製薬化学科.薬品素材学講座 (〜2006年3月31日)
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| 2. | 徳島大学.ゲノム機能研究センター (〜2008年3月31日/->組織[徳島大学.疾患プロテオゲノム研究センター])
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| ○著者 (必須): | 1. | (英) Kajimoto Kazuaki (日) (読)
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| 2. | 山﨑 尚志 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学]/[徳島大学.薬学部.創製薬科学科.創薬学講座.衛生薬学]/[徳島大学.薬学研究科.創薬科学専攻])
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| 3. | 片岡 正俊
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| 4. | 寺田 弘 ([東京理科大学])
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| 5. | 篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| ○題名 (必須): | □ | (英) Identification of possible protein machinery involved in the thermogenic function of brown adipose tissue. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Brown adipose tissue (BAT) is believed to function by dissipating excess energy in mammals. It is very important to understand the energy metabolism held in BAT since disorder of its energy-dissipating function may cause obesity or lifestyle-related diseases such as hypertension and diabetes. This function in BAT is mainly attributable to uncoupling protein (UCP), specifically expressed in its mitochondria. This protein consumes excess energy as heat by dissipating the H+ gradient across the inner mitochondrial membrane that is utilized as a driving force for ATP synthesis. In this review article, in addition to providing a brief introduction to the functional properties of BAT and UCP, we also describe and discuss properties of cultured brown adipocytes and the results of our exploratory studies on protein components involved in the energy-dissipating function in BAT. (日)
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| ○キーワード (推奨): | 1. | (英) Adipose Tissue, Brown (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Calcium Channels (日) (読)
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| 4. | (英) Carrier Proteins (日) (読)
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| 5. | (英) Energy Metabolism (日) (読)
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| 6. | (英) Gene Expression Profiling (日) (読)
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| 7. | (英) Humans (日) (読)
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| 8. | (英) Inositol 1,4,5-Trisphosphate Receptors (日) (読)
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| 9. | (英) Ion Channels (日) (読)
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| 10. | (英) Membrane Proteins (日) (読)
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| 11. | (英) Mitochondrial Proteins (日) (読)
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| 12. | (英) Oligonucleotide Array Sequence Analysis (日) (読)
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| 13. | (英) Polymerase Chain Reaction (日) (読)
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| 14. | (英) Proteins (日) (読)
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| 15. | (英) Receptors, Cytoplasmic and Nuclear (日) (読)
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| 16. | (英) Thermogenesis (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1343-1420
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 51
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| ○号 (必須): | □ | 1-2
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| ○頁 (必須): | □ | 20 28
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2004年 2月 初日 (平成 16年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.51.20 (→Scopusで検索)
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| ○PMID (任意): | □ | 15000252 (→Scopusで検索)
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| ○CRID (任意): |
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| ○機関リポジトリ : | □ | 110710
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| ○researchmap (任意): |
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Review (日)
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| 3. | (英) NumberOfReferences: 46 (日)
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