『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=84807)

EID=84807EID:84807, Map:0, LastModified:2013年6月16日(日) 18:51:36, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[山﨑 尚志], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.薬学部.製薬化学科.薬品素材学講座 (〜2006年3月31日) [継承]
2.徳島大学.ゲノム機能研究センター (〜2008年3月31日/->組織[徳島大学.疾患プロテオゲノム研究センター]) [継承]
著者 (必須): 1. (英) Kajimoto Kazuaki (日) (読)
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[継承]
2. (英) Daikoku Takiko (日) (読)
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学籍番号 (推奨):
[継承]
3.山﨑 尚志 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.薬物治療学])
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学籍番号 (推奨):
[継承]
4.寺田 弘 ([東京理科大学])
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学籍番号 (推奨):
[継承]
5.篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Expression profiles of three isoforms of inositol 1,4,5-trisphosphate receptor in brown adipose tissue of the rat.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The thermogenic function of brown adipose tissue (BAT) is known to be mainly regulated by a signal transduction cascade via beta-adrenoceptor. However, recent studies indicated that the alpha-adrenoceptor and its downstream signal transduction cascade, causing elevation of the cellular Ca(2+) level, are also important for the regulation of this function of BAT. In the present study, expression profiles of 3 isoforms of the inositol 1,4,5-trisphosphate (IP(3)) receptor, known as one of the major components of the machinery regulating the intracellular Ca(2+) concentration in the BAT of rats, were investigated by Northern analysis. Of these three IP(3) receptor isoforms, the type 2 one was found to be the most abundant of the three in BAT. Furthermore, when rats were exposed to the cold, under which condition the thermogenic function of BAT is known to be stimulated, the expression levels of types 1 and 2 isoforms of IP(3) receptor were remarkably elevated. The results of Western analysis supported the predominant expression of the type 2 isoform in BAT. However, different from the results of Northern analysis, the expression levels of types 1 and 2 isoforms of IP(3) receptor protein in BAT were not influenced by exposure of the animals to the cold.  (日)    [継承]
キーワード (推奨): 1. (英) Adipose Tissue, Brown (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Blotting, Northern (日) (読) [継承]
4. (英) Calcium Channels (日) (読) [継承]
5. (英) Energy Metabolism (日) (読) [継承]
6. (英) Gene Expression Profiling (日) (読) [継承]
7. (英) Inositol 1,4,5-Trisphosphate Receptors (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Protein Isoforms (日) (読) [継承]
10. (英) Rats (日) (読) [継承]
11. (英) Rats, Wistar (日) (読) [継承]
12. (英) Receptors, Cytoplasmic and Nuclear (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochemical Pharmacology ([Elsevier Science])
(pISSN: 0006-2952, eISSN: 1873-2968)

ISSN (任意): 0006-2952
ISSN: 0006-2952 (pISSN: 0006-2952, eISSN: 1873-2968)
Title: Biochemical pharmacology
Title(ISO): Biochem Pharmacol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 995 998 [継承]
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年月日 (必須): 西暦 2003年 3月 15日 (平成 15年 3月 15日) [継承]
URL (任意):
DOI (任意): 10.1016/S0006-2952(02)01664-7    (→Scopusで検索) [継承]
PMID (任意): 12623131    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi-1, Tokushima 770-8505, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kazuaki Kajimoto, Takiko Daikoku, Naoshi Yamazaki, Hiroshi Terada and Yasuo Shinohara : Expression profiles of three isoforms of inositol 1,4,5-trisphosphate receptor in brown adipose tissue of the rat., Biochemical Pharmacology, Vol.65, No.6, 995-998, 2003.
欧文冊子 ● Kazuaki Kajimoto, Takiko Daikoku, Naoshi Yamazaki, Hiroshi Terada and Yasuo Shinohara : Expression profiles of three isoforms of inositol 1,4,5-trisphosphate receptor in brown adipose tissue of the rat., Biochemical Pharmacology, Vol.65, No.6, 995-998, 2003.

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