| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): | 1. | 徳島大学.分子酵素学研究センター (〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター])
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| ○著者 (必須): | 1. | 坂井 隆志
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| ○学籍番号 (推奨): |
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| 2. | 劉 莉 ([徳島大学.分子酵素学研究センター])
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| 3. | 宍戸 裕二
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| 4. | 福井 清 ([徳島大学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Identification of a Novel, Embryonal Carcinoma Cell-Associated Molecule, Nucling, That Is Up-regulated during Cardiac Muscle Differentiation (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) EC cells are characterized by their potent capacity to differentiate into several cell types, such as mesoderm-like cells, endoderm-like cells, or ectoderm-like cells. By subtracting the mRNAs expressed by one EC cell clone, F9 cells, with the mRNAs expressed by another EC cell clone, P19 cells, we identified six novel genes that are expressed selectively by F9 cells. One of these genes (Nucling) encodes a polypeptide of 1411 amino acids containing an ankyrin repeat, aspartyl protease motif, a leucine zipper motif, and two t-SNARE coiled-coil domains. Northern blot analyses revealed the Nucling mRNA to be detected predominantly in heart, liver, kidney and testis, but not in brain or spleen. Immunostaining analyses revealed a unique feature of Nucling that the transiently expressed protein forms aggregates exclusively around nuclear membranes. Moreover, the expression level of the Nucling gene transcript increases progressively during the early developmental stages in mice, and specifically at cardiomuscular differentiation in vitro and in vivo. These results suggest that Nucling may play some role in the gene regulation of cell differentiation during embryonal development. (日)
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| ○キーワード (推奨): | 1. | 心筋分化 (cardiomuscular differentiation)
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| 2. | cDNA subtractive screening (cDNA subtractive screening)
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| 3. | 細胞分化 (cell differentiation)
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| 4. | EC細胞 (EC cells)
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| 5. | 胚発生 (embryonal development)
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| ○発行所 (推奨): | □ | 日本生化学会
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| ○誌名 (必須): | □ | The Journal of Biochemistry ([日本生化学会])
(pISSN: 0021-924X, eISSN: 1756-2651)
| ○ISSN (任意): | □ | 0021-924X
ISSN: 0021-924X
(pISSN: 0021-924X, eISSN: 1756-2651) Title: Journal of biochemistryTitle(ISO): J BiochemSupplier: Oxford University PressPublisher: Oxford University Press (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 133
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 429 436
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| ○都市 (任意): | □ | 東京 (Tokyo/[日本国])
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| ○年月日 (必須): | □ | 西暦 2003年 4月 1日 (平成 15年 4月 1日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1093/jb/mvg056 (→Scopusで検索)
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| ○PMID (任意): | □ | 12761289 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000182681500005
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| ○備考 (任意): | 1. | (英) Article.Affiliation: The Institute for Enzyme Research, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima, 770-8503. (日)
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| 2. | (英) Article.DataBankList.DataBank.DataBankName: GENBANK (日)
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| 3. | (英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: AB030647 (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 5. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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