『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨): 1.徳島大学.総合科学部.自然システム学科 (1993年4月1日〜) [継承]
著者 (必須): 1. (英) Nakao Hiromi (日) (読)
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2. (英) Senokuchi Kaori (日) (読)
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3. (英) Umebayashi Chisato (日) (読)
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4.金丸 芳 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.食料科学講座])
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5.増田 俊哉
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6.小山 保夫
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7. (英) Yonemori Shigetomo (日) (読)
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題名 (必須): (英) Cytotoxic activity of maytanprine isolated from Maytenus diversifolia in human leukemia K562 cells  (日)    [継承]
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要約 (任意): (英) We examined the cytotoxic effect of maytanprine isolated from the methanol extract of Maytenus diversifolia on human leukemia K562 cells using a flow cytometer and compared its cytotoxicity with that of maytansine, a potent cytotoxic maytansinoid. Maytanprine at concentrations of 0.03 nM or more (up to 1 nM) attenuated cell growth with decreasing cell viability and increased the population of shrunken cells in a concentration-dependent manner. Complete inhibition of growth by maytanprine was observed at concentrations of 0.3 nM or more. The compound at 0.03 nM markedly decreased the population at G0G1 phase in the cell cycle, but only slightly decreased that in the G2M phase, suggesting the possibility that it inhibits or delays cell division, and increased the population of cells with hypodiploidal DNA (apoptotic cells). The potency of maytanprine in inhibiting cell growth was greater than that of maytansine, although the inhibitory action of maytanprine was similar to that of maytansine. The results suggest that maytanprine exerts a potent inhibitory action on the growth of human leukemia K562 cells. M. diversifolia is one natural source of maytanprine, which is more cytotoxic than maytansine.  (日)    [継承]
キーワード (推奨): 1. (英) Antineoplastic Agents (日) (読) [継承]
2. (英) Cell Division (日) (読) [継承]
3. (英) Flow Cytometry (日) (読) [継承]
4. (英) Humans (日) (読) [継承]
5. (英) K562 Cells (日) (読) [継承]
6. (英) Maytansine (日) (読) [継承]
発行所 (推奨): 日本薬学会 [継承]
誌名 (必須): Biological & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0918-6158, eISSN: 1347-5215)

ISSN (任意): 0918-6158
ISSN: 0918-6158 (pISSN: 0918-6158, eISSN: 1347-5215)
Title: Biological & pharmaceutical bulletin
Title(ISO): Biol Pharm Bull
Supplier: 公益社団法人日本薬学会
Publisher: Pharmaceutical Society of Japan
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 27 [継承]
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(必須): 1236 1240 [継承]
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年月日 (必須): 西暦 2004年 10月 初日 (平成 16年 10月 初日) [継承]
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DOI (任意): 10.1248/bpb.27.1236    (→Scopusで検索) [継承]
PMID (任意): 15305028    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Laboratories of Cell Signaling and Bioorganic Chemistry, Faculty of Integrated Arts and Sciences, The University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hiromi Nakao, Kaori Senokuchi, Chisato Umebayashi, Kaori Kanemaru, Toshiya Masuda, Yasuo Oyama and Shigetomo Yonemori : Cytotoxic activity of maytanprine isolated from Maytenus diversifolia in human leukemia K562 cells, Biological & Pharmaceutical Bulletin, Vol.27, No.8, 1236-1240, 2004.
欧文冊子 ● Hiromi Nakao, Kaori Senokuchi, Chisato Umebayashi, Kaori Kanemaru, Toshiya Masuda, Yasuo Oyama and Shigetomo Yonemori : Cytotoxic activity of maytanprine isolated from Maytenus diversifolia in human leukemia K562 cells, Biological & Pharmaceutical Bulletin, Vol.27, No.8, 1236-1240, 2004.

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