『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=73488EID:73488, Map:0, LastModified:2015年1月5日(月) 11:13:30, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.工学部.生物工学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.薬学部.薬学科 [継承]
著者 (必須): 1.後藤 了
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Guo Zong-Ru (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Futatsuishi Yukako (日) (読)
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4.堀 均
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5.平良 全栄 ([徳島文理大学])
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学籍番号 (推奨):
[継承]
6.寺田 弘 ([東京理科大学])
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[継承]
題名 (必須): (英) Quantitative structure-activity relationships of benzamide derivatives for anti-leukotriene activities  (日)    [継承]
副題 (任意):
要約 (任意): (英) To determine the structural requirements of the benzamide derivatives reported by Nakai et al. (J. Med. Chem. 1988, 31, 84-91) for antileukotriene activity, we studied their conformational characteristics in comparison with those of leukotriene. By superimpositions of the conformations of antagonists on that of leukotriene, we found that the conformations of the conjugated benzamide moiety, tetrazole ring, and benzopyran or benzodioxan ring of the antagonists correspond to the triene moiety, peptide carboxylic acid residue, and cysteine residue of leukotriene, respectively, but that no moiety of the antagonists corresponds to the terminal aliphatic carboxylic acid moiety of leukotriene. Furthermore, the stable conformations of alkyl and alkoxy groups of the antagonists were quite different from that of the omega-chain of leukotriene. However, conformational analyses taking all the possible rotations of these flexible chains into consideration showed that antagonists in which these flexible chains can most feasibly adopt the same lengths as those of the omega-chain exhibit potent antagonist activity. From these results, we deduced the structural features of benzamide derivatives necessary for potent antileukotriene activity.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Benzamides (日) (読) [継承]
3. (英) Guinea Pigs (日) (読) [継承]
4. (英) Ileum (日) (読) [継承]
5. (英) In Vitro Techniques (日) (読) [継承]
6. (英) Leukotriene Antagonists (日) (読) [継承]
7. (英) Leukotrienes (日) (読) [継承]
8. (英) Molecular Conformation (日) (読) [継承]
9. (英) Muscle Contraction (日) (読) [継承]
10. (英) Muscle, Smooth (日) (読) [継承]
11.構造活性相関 (structureactivity relationship) [継承]
発行所 (推奨): アメリカ化学会 [継承]
誌名 (必須): Journal of Medicinal Chemistry ([アメリカ化学会])
(pISSN: 0022-2623, eISSN: 1520-4804)

ISSN (任意): 0022-2623
ISSN: 0022-2623 (pISSN: 0022-2623, eISSN: 1520-4804)
Title: Journal of medicinal chemistry
Title(ISO): J. Med. Chem.
Publisher: American Chemical Society
 (NLM Catalog  (CrossRef (Scopus information is found. [need login])
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(必須): 35 [継承]
(必須): 13 [継承]
(必須): 2440 2445 [継承]
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年月日 (必須): 西暦 1992年 6月 26日 (平成 4年 6月 26日) [継承]
URL (任意):
DOI (任意): 10.1021/jm00091a011    (→Scopusで検索) [継承]
PMID (任意): 1619618    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Satoru GOTO, Zong-Ru Guo, Yukako Futatsuishi, Hitoshi Hori, Zenei Taira and Hiroshi Terada : Quantitative structure-activity relationships of benzamide derivatives for anti-leukotriene activities, Journal of Medicinal Chemistry, Vol.35, No.13, 2440-2445, 1992.
欧文冊子 ● Satoru GOTO, Zong-Ru Guo, Yukako Futatsuishi, Hitoshi Hori, Zenei Taira and Hiroshi Terada : Quantitative structure-activity relationships of benzamide derivatives for anti-leukotriene activities, Journal of Medicinal Chemistry, Vol.35, No.13, 2440-2445, 1992.

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