『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=73470EID:73470, Map:0, LastModified:2015年1月5日(月) 13:35:36, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.工学部.生物工学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.薬学部.薬学科 [継承]
著者 (必須): 1.真島 英司 (アプロサイエンス)
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2.後藤 了
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3.堀 均
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4.篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
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5. (英) Hong Yeong-Man (日) (読)
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6.寺田 弘 ([東京理科大学])
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題名 (必須): (英) Stablilities of the fluorescent SH-reagent eosin-5-maleimide and its adducts with sulfhydryl compounds  (日)    [継承]
副題 (任意):
要約 (任意): (英) The stabilities of the SH-reagent eosin-5-maleimide (EMA) and its adducts with the SH-compounds L-cysteine, N-acetyl-L-cysteine and glutathione (reduced form) were studied under various conditions in comparison with those of the adducts of N-ethylmaleimide (NEM). Studies by reversed-phase high performance liquid chromatography and mass spectrometry showed that EMA was less stable than NEM at neutral and moderately alkaline pH values. EMA formed a succinimide-type adduct with SH-compounds, and then underwent further modification by nucleophilic attack of OH- or an amino group. The succinimide-type adducts with acetylcysteine and glutathione were converted to open-type adducts, in which the succinimide ring was cleaved, whereas the adduct with cysteine was modified to a thiazine-type adduct. Kinetic analyses showed that these open-type and thiazine-type adducts were readily formed and were stable at moderately alkaline pH values such as pH 8.0 or 9.0.  (日)    [継承]
キーワード (推奨): 1. (英) Acetylcysteine (日) (読) [継承]
2. (英) Chromatography, High Pressure Liquid (日) (読) [継承]
3. (英) Cysteine (日) (読) [継承]
4. (英) Drug Stability (日) (読) [継承]
5. (英) Eosine Yellowish-(YS) (日) (読) [継承]
6. (英) Ethylmaleimide (日) (読) [継承]
7. (英) Glutathione (日) (読) [継承]
8. (英) Hydrogen-Ion Concentration (日) (読) [継承]
9. (英) Kinetics (日) (読) [継承]
10.質量分析法 (mass spectrometry) [継承]
11. (英) Spectrometry, Fluorescence (日) (読) [継承]
12. (英) Spectrometry, Mass, Fast Atom Bombardment (日) (読) [継承]
13. (英) Succinimides (日) (読) [継承]
14. (英) Sulfhydryl Compounds (日) (読) [継承]
発行所 (推奨): Elsevier Science [継承]
誌名 (必須): Biochimica et Biophysica Acta (BBA) - General Subjects ([Elsevier Science])
(pISSN: 0304-4165)

ISSN (任意): 0304-4165
ISSN: 0304-4165 (pISSN: 0304-4165, eISSN: 1872-8006)
Title: Biochimica et biophysica acta. General subjects
Title(ISO): Biochim Biophys Acta Gen Subj
Publisher: Elsevier BV
 (NLM Catalog  (CrossRef (Scopus information is found. [need login])
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(必須): 1243 [継承]
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(必須): 336 342 [継承]
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年月日 (必須): 西暦 1995年 4月 13日 (平成 7年 4月 13日) [継承]
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DOI (任意): 10.1016/0304-4165(94)00159-U    (→Scopusで検索) [継承]
PMID (任意): 7537101    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-0028970124 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Eiji Majima, Satoru GOTO, Hitoshi Hori, Yasuo Shinohara, Yeong-Man Hong and Hiroshi Terada : Stablilities of the fluorescent SH-reagent eosin-5-maleimide and its adducts with sulfhydryl compounds, Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1243, No.3, 336-342, 1995.
欧文冊子 ● Eiji Majima, Satoru GOTO, Hitoshi Hori, Yasuo Shinohara, Yeong-Man Hong and Hiroshi Terada : Stablilities of the fluorescent SH-reagent eosin-5-maleimide and its adducts with sulfhydryl compounds, Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1243, No.3, 336-342, 1995.

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