『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=73203)

EID=73203EID:73203, Map:0, LastModified:2015年1月15日(木) 13:51:58, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.京都大学 [継承]
著者 (必須): 1. (英) Masunaga Shin-ichiro (日) (読)
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[継承]
2. (英) Ono Koji (日) (読)
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3. (英) Kirihata Mitsunori (日) (読)
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4. (英) Takagaki Masao (日) (読)
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[継承]
5. (英) Sakurai Yoshinori (日) (読)
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[継承]
6. (英) Kinashi Yuko (日) (読)
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[継承]
7. (英) Kobayashi Tooru (日) (読)
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[継承]
8. (英) Suzuki Minoru (日) (読)
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[継承]
9. (英) Nagata Kenji (日) (読)
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10.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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11.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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12.堀 均
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題名 (必須): (英) Potential of α-amino alcohol p-boronophenylalaninol as a boron carrier in boron neutron capture therapy, regarding its enantiomers  (日)    [継承]
副題 (任意):
要約 (任意): (英) We evaluated the potential of a newly developed (10)B-containing alpha-amino alcohol of p-boronophenylalanine-(10)B (BPA), p-boronophenylalaninol (BPAol), as a boron carrier in boron neutron capture therapy. C57BL mice bearing EL4 tumors received 5-bromo-2'-deoxyuridine (BrdU) continuously via implanted mini-osmotic pumps to label all proliferating (P) cells. After oral administration of L-BPA or D-BPA, or intraperitoneal injection of L-BPAol or D-BPAol, the tumors were irradiated with reactor thermal neutron beams. Some of the tumors were heated at 40 degrees C for 30 min (mild temperature hyperthermia (MTH)) right before neutron exposure, and/or tirapazamine (TPZ) was intraperitoneally injected 30 min before irradiation. The tumors were then excised, minced, and trypsinized. The tumor cell suspensions thus obtained were incubated with cytochalasin-B (a cytokinesis blocker), and the micronucleus (MN) frequency in cells without BrdU labeling [ =quiescent (Q) cells] was determined using immunofluorescence staining for BrdU. Meanwhile, 6 h after irradiation, tumor cell suspensions obtained in the same manner were used for determining the apoptosis frequency in Q cells. The apoptosis and MN frequency in total (P+Q) tumor cells were determined from the tumors that were not pretreated with BrdU. Without TPZ or MTH, L- and D-BPAol increased both frequencies markedly, especially for total cells. Although not significantly larger, L-BPA and D-BPAol increased both frequencies slightly more than D-BPA and L-BPAol, respectively. Combination with both MTH and TPZ markedly reduced the sensitivity difference between total and Q cells. Both L- and D-BPAol have potential as a (10)B-carrier in neutron capture therapy, especially when combined with both MTH and TPZ.  (日)    [継承]
キーワード (推奨): 1. (英) Amino Alcohols (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Apoptosis (日) (読) [継承]
4. (英) Boranes (日) (読) [継承]
5. (英) Boron Neutron Capture Therapy (日) (読) [継承]
6. (英) Dose-Response Relationship, Drug (日) (読) [継承]
7. (英) Dose-Response Relationship, Radiation (日) (読) [継承]
8. (英) Drug Carriers (日) (読) [継承]
9. (英) Female (日) (読) [継承]
10. (英) Fluorescent Antibody Technique (日) (読) [継承]
11. (英) Hyperthermia, Induced (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Inbred C57BL (日) (読) [継承]
14. (英) Phenylalanine (日) (読) [継承]
15. (英) Radiation-Sensitizing Agents (日) (読) [継承]
16. (英) Radiotherapy Dosage (日) (読) [継承]
17. (英) Triazines (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Cancer Research and Clinical Oncology (Deutsche Krebsgesellschaft e.V.)
(pISSN: 0171-5216, eISSN: 1432-1335)

ISSN (任意): 0171-5216
ISSN: 0171-5216 (pISSN: 0171-5216, eISSN: 1432-1335)
Title: Journal of cancer research and clinical oncology
Title(ISO): J. Cancer Res. Clin. Oncol.
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 129 [継承]
(必須): 1 [継承]
(必須): 21 28 [継承]
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年月日 (必須): 西暦 2003年 1月 11日 (平成 15年 1月 11日) [継承]
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DOI (任意): 10.1007/s00432-002-0397-3    (→Scopusで検索) [継承]
PMID (任意): 12618897    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Noda, Kumatori-cho, Sennan-gun, 590-0494, Osaka, Japan. smasuna@rri.kyoto-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shin-ichiro Masunaga, Koji Ono, Mitsunori Kirihata, Masao Takagaki, Yoshinori Sakurai, Yuko Kinashi, Tooru Kobayashi, Minoru Suzuki, Kenji Nagata, Hideko Nagasawa, Yoshihiro Uto and Hitoshi Hori : Potential of α-amino alcohol p-boronophenylalaninol as a boron carrier in boron neutron capture therapy, regarding its enantiomers, Journal of Cancer Research and Clinical Oncology, Vol.129, No.1, 21-28, 2003.
欧文冊子 ● Shin-ichiro Masunaga, Koji Ono, Mitsunori Kirihata, Masao Takagaki, Yoshinori Sakurai, Yuko Kinashi, Tooru Kobayashi, Minoru Suzuki, Kenji Nagata, Hideko Nagasawa, Yoshihiro Uto and Hitoshi Hori : Potential of α-amino alcohol p-boronophenylalaninol as a boron carrier in boron neutron capture therapy, regarding its enantiomers, Journal of Cancer Research and Clinical Oncology, Vol.129, No.1, 21-28, 2003.

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