『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨): 1.徳島大学.歯学部.歯学科 [継承]
著者 (必須): 1. (英) Saegusa, Kaoru (日) (読)
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学籍番号 (推奨):
[継承]
2.石丸 直澄 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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学籍番号 (推奨):
[継承]
3. (英) Yanagi, Kumiko (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Haneji, Norio (日) (読)
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[継承]
5.西野 瑞穗
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[継承]
6.東 雅之
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学籍番号 (推奨):
[継承]
7. (英) Saito, Ichiro (日) (読)
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[継承]
8.林 良夫
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[継承]
題名 (必須): (英) Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjogren's syndrome  (日)    [継承]
副題 (任意):
要約 (任意): (英) Organ-specific autoimmune exocrinopathy resembling Sjögren's syndrome (SS) that spontaneously develops in NFS/sld mutant mice thymectomized 3 day after birth is dependent on Th1-type CD4+ T cells. We previously reported that a cleavage product of 120-kDa alpha-fodrin may be an important autoantigen in the pathogenesis of SS in both an animal model and the patients. We demonstrate that in an animal model of SS with overt exocrinopathy, a unique CD4+ T cell subset expressing CD28low is dramatically increased in spleen cells before the disease onset, but that the CD4+ T cells of diseased mice were virtually all CD28high. We found that the spleen cells in these mice before the disease onset showed a significant increase in autoantigen-specific T cell proliferation. Analysis of in vitro cytokine production by spleen cells indicated, before the disease onset, severely impaired production of IL-2 and IFN-gamma in the animal model, whereas high levels of IL-4 were observed. Expression of cytokine genes, including IL-4, IL-10, and TGF-beta, was detected in FACS-sorted CD4+CD28low T cells by RT-PCR analysis. Transfer of CD4+CD28low T cells into the animal model actually prevented the development of autoimmune lesions including autoantibody production. These results suggest that a CD4+CD28low T cell subset that is continuously activated by an organ-specific autoantigen may play a regulatory role in the development of organ-specific autoimmune disease in an animal model of SS.  (日)    [継承]
キーワード (推奨): 1. (英) Adoptive Transfer (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Autoantigens (日) (読) [継承]
4. (英) CD28 Antigens (日) (読) [継承]
5. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
6. (英) Carrier Proteins (日) (読) [継承]
7. (英) Cells, Cultured (日) (読) [継承]
8. (英) Epitopes, T-Lymphocyte (日) (読) [継承]
9. (英) Female (日) (読) [継承]
10. (英) Flow Cytometry (日) (読) [継承]
11. (英) Injections, Intraperitoneal (日) (読) [継承]
12. (英) Lymphocyte Activation (日) (読) [継承]
13. (英) Mice (日) (読) [継承]
14. (英) Mice, Inbred BALB C (日) (読) [継承]
15. (英) Mice, Inbred C57BL (日) (読) [継承]
16. (英) Mice, Mutant Strains (日) (読) [継承]
17. (英) Microfilament Proteins (日) (読) [継承]
18. (英) Sjogren's Syndrome (日) (読) [継承]
19. (英) T-Lymphocyte Subsets (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 165 [継承]
(必須): 4 [継承]
(必須): 2251 2257 [継承]
都市 (任意):
年月日 (必須): 西暦 2000年 8月 15日 (平成 12年 8月 15日) [継承]
URL (任意):
DOI (任意): 10.4049/jimmunol.165.4.2251    (→Scopusで検索) [継承]
PMID (任意): 10925313    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000088626200067 [継承]
Scopus (任意): 2-s2.0-0034664060 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Norio Haneji, Mizuho Nishino, Masayuki Azuma, Ichiro Saito and Yoshio Hayashi : Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjogren's syndrome, The Journal of Immunology, Vol.165, No.4, 2251-2257, 2000.
欧文冊子 ● Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Norio Haneji, Mizuho Nishino, Masayuki Azuma, Ichiro Saito and Yoshio Hayashi : Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjogren's syndrome, The Journal of Immunology, Vol.165, No.4, 2251-2257, 2000.

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