『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=72392EID:72392, Map:0, LastModified:2017年12月22日(金) 11:20:48, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[赤松 徹也], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.歯学部.歯学科 [継承]
著者 (必須): 1.赤松 徹也 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意): 共著 [継承]
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Parvin, Nahid Most (日) (読)
役割 (任意): 共著 [継承]
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Murdiastuti, Kwartarini (日) (読)
役割 (任意): 共著 [継承]
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.小杉 知里
役割 (任意): 共著 [継承]
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.姚 陳娟 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
役割 (任意): 共著 [継承]
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Miki, Osamu (日) (読)
役割 (任意): 共著 [継承]
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.金森 憲雄
役割 (任意): 共著 [継承]
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学籍番号 (推奨):
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8.細井 和雄
役割 (任意): 共著 [継承]
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Expression and localization of aquaporins, members of the water channel family, during development of the rat submandibular gland.  (日)    [継承]
副題 (任意):
要約 (任意): (英) The expression and localization of aquaporins (AQP1-AQP5), members of the water channel family, in the developing rat submandibular gland were analysed using RT-PCR, Northern blotting and immunohistochemistry to explore their relation to the development of this salivary gland. RT-PCR analysis revealed unique expression patterns of each AQP. AQP1 was expressed constitutively during prenatal development, whereas the expression of AQP5 became more intense in the course of development from embryonic day 16.5 (E16) to E20. These expression patterns concurred with the results of Northern blot analysis. AQP3 and AQP4 mRNAs in the prenatal development were not detected in Northern blots, although they were detected by RT-PCR. During postnatal development, AQP5 and AQP1 mRNAs were expressed continuously, but no message for AQP3 or AQP4 was detected. AQP2 mRNA was not detected during either prenatal or postnatal development in this tissue. Immunohistochemical studies revealed that AQP5 was first localized at the apical membrane of proacinar cells at E18, and then became clearly distributed at the apical membrane of acinar cells in accordance with the differentiation and establishment of the mature acini. In addition, some vasculature also showed immunoreactivity for AQP5. AQP1 was immunolocalized in the blood vessels, including capillaries, of the gland throughout development. These observations suggest the existence of transcriptional regulation of rat AQP5, which is one of the most probable regulators of saliva production and secretion, during the establishment of the functional submandibular salivary gland.  (日) ラット顎下腺発生過程でのAQPファミリーの発現を解析した.AQP3,4は胎生期に非常に弱く発現するが,AQP1,5は胎生期から生後を通して発現し続ける.AQP1は血管にのみ局在するのに対して,AQP5は胎生18日の未分化腺房細胞管腔膜への局在以後,分化成熟につれ腺房細胞の他,一部の血管にも局在する.発生過程を通しAQP5が唾液の産生·分泌に中心的役割を果たすと考えられる.   [継承]
キーワード (推奨): 1. (英) Aging (日) (読) [継承]
2. (英) Amino Acid Sequence (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Aquaporins (日) (読) [継承]
5. (英) Biological Transport, Active (日) (読) [継承]
6. (英) Blotting, Northern (日) (読) [継承]
7. (英) Body Water (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Immunohistochemistry (日) (読) [継承]
10. (英) Molecular Sequence Data (日) (読) [継承]
11. (英) Pregnancy (日) (読) [継承]
12. (英) RNA (日) (読) [継承]
13. (英) RNA, Antisense (日) (読) [継承]
14. (英) Rats (日) (読) [継承]
15. (英) Rats, Sprague-Dawley (日) (読) [継承]
16. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
17. (英) Sodium-Potassium-Exchanging ATPase (日) (読) [継承]
18. (英) Submandibular Gland (日) (読) [継承]
発行所 (推奨): Springer-Verlag [継承]
誌名 (必須): Pflügers Archiv : European Journal of Physiology ([Springer-Verlag])
(pISSN: 0031-6768, eISSN: 1432-2013)

ISSN (任意): 0031-6768
ISSN: 0031-6768 (pISSN: 0031-6768, eISSN: 1432-2013)
Title: Pflugers Archiv : European journal of physiology
Title(ISO): Pflugers Arch
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 446 [継承]
(必須): 6 [継承]
(必須): 641 651 [継承]
都市 (任意):
年月日 (必須): 西暦 2003年 6月 28日 (平成 15年 6月 28日) [継承]
URL (任意):
DOI (任意): 10.1007/s00424-003-1109-9    (→Scopusで検索) [継承]
PMID (任意): 12838423    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000185394800002 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tetsuya Akamatsu, Most Nahid Parvin, Kwartarini Murdiastuti, Chisato Kosugi, Chenjuan Yao, Osamu Miki, Norio Kanamori and Kazuo Hosoi : Expression and localization of aquaporins, members of the water channel family, during development of the rat submandibular gland., Pflügers Archiv : European Journal of Physiology, Vol.446, No.6, 641-651, 2003.
欧文冊子 ● Tetsuya Akamatsu, Most Nahid Parvin, Kwartarini Murdiastuti, Chisato Kosugi, Chenjuan Yao, Osamu Miki, Norio Kanamori and Kazuo Hosoi : Expression and localization of aquaporins, members of the water channel family, during development of the rat submandibular gland., Pflügers Archiv : European Journal of Physiology, Vol.446, No.6, 641-651, 2003.

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