『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
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○カテゴリ (推奨):
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○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1.佐藤 光信
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2.岡本 正人
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3. (英) Ohe Go (日) 大江 剛 (読) おおえ ごう
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4. (英) Furuichi Sachiko (日) 古市 幸子 (読) ふるいち さちこ
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5. (英) Nishikawa Hidetomo (日) 西川 英知 (読) にしかわ ひでとも
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6. (英) Oshikawa Tetsuya (日) 押川 哲也 (読) おしかわ てつや
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7. (英) Tano Tomoyuki (日) 田野 智之 (読) たの ともゆき
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8. (英) Ahmed SU (日) (読) ショリフ ウディン アーメッド
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9.吉田 秀夫
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○題名 (必須): □(英) Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal agent, in athymic nude mice bearing human salivary adenocarcinoma: Role of natural killer cells  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) OK-PSA, a lipoteichoic acid (LTA)-related molecule isolated from a streptococcal agent OK-432, enhances anti-tumor immunity as a potent inducer of Th1-type cytokines. Recently, we obtained the data suggesting that natural killer (NK) cells may play a significant role for OK-PSA-induced cytokine production in vitro. We conducted the animal experiments using athymic nude mice bearing human salivary adenocarcinoma to examine the role of NK cells in OK-PSA-induced anti-tumor immunity. OK-PSA was peritumorally injected into the mice. Cytokines in the sera were analyzed by ELISA. mRNAs for cytokines were detected by RT-PCR. 51Cr release test was performed to measure killer cell activities. OK-PSA markedly increased the amounts of IFN-gamma, tumor necrosis factor (TNF)-alpha, interleukin (IL)-2, IL-12 and IL-18 that are generally called "Th1-type cytokines" in the sera derived from tumor-bearing nude mice, and also accelerated the killing activities of tumor-infiltrating lymphocytes as well as of draining lymph node cells. Furthermore, OK-PSA administration resulted in significant inhibition of tumor growth, but the effect of OK-PSA was almost completely inhibited by the deletion of NK cells using anti-asialo GM1 antibody. These findings strongly suggested that NK cells are closely involved in OK-PSA-mediated anti-tumor immunity.  (日)    [継承]
○キーワード (推奨): 1. (英) Adenocarcinoma (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antibodies (日) (読) [継承]
4. (英) Cell Movement (日) (読) [継承]
5. (英) Combined Modality Therapy (日) (読) [継承]
6.細胞質分裂 (cytokinesis) [継承]
7. (英) G(M1) Ganglioside (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9.免疫療法 (immunotherapy) [継承]
10. (英) Killer Cells, Natural (日) (読) [継承]
11. (英) Lipopolysaccharides (日) (読) [継承]
12. (英) Lymphocytes (日) (読) [継承]
13. (英) Lymphocytes, Tumor-Infiltrating (日) (読) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Mice (日) (読) [継承]
16. (英) Mice, Inbred BALB C (日) (読) [継承]
17. (英) Mice, Nude (日) (読) [継承]
18.一酸化窒素 (nitric oxide) [継承]
19. (英) Nitric Oxide Synthase (日) (読) [継承]
20. (英) Nitric Oxide Synthase Type II (日) (読) [継承]
21. (英) Picibanil (日) (読) [継承]
22. (英) RNA, Messenger (日) (読) [継承]
23. (英) Salivary Gland Neoplasms (日) (読) [継承]
24. (英) Teichoic Acids (日) (読) [継承]
25. (英) Th1 Cells (日) (読) [継承]
26. (英) Xenograft Model Antitumor Assays (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Anticancer Research (International Institute of Anticancer Research(IIAR))
(pISSN: 0250-7005, eISSN: 1791-7530)

○ISSN (任意): □0250-7005
ISSN: 0250-7005 (pISSN: 0250-7005, eISSN: 1791-7530)
Title: Anticancer research
Title(ISO): Anticancer Res
Publisher: International Institute of Anticancer Research
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □22 [継承]
○号 (必須): □6A [継承]
○頁 (必須): □3229 3240 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2002年 11月 初日 (平成 14年 11月 初日) [継承]
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○PMID (任意): □12530069    (→Scopusで検索) [継承]
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○Scopus (任意): □2-s2.0-0036870654 [継承]
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○備考 (任意): 1.(英) Article.Affiliation: Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, 3-18-15 Kuramoto-cho, Tokushima 7708504, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) MedlineDate: 2002 Nov-Dec  (日)    [継承]

標準的な表示

和文冊子 ● Mitsunobu Sato, Masato Okamoto, Go Ohe, Sachiko Furuichi, Hidetomo Nishikawa, Tetsuya Oshikawa, Tomoyuki Tano, SU Ahmed and Hideo Yoshida : Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal agent, in athymic nude mice bearing human salivary adenocarcinoma: Role of natural killer cells, Anticancer Research, Vol.22, No.6A, 3229-3240, 2002.
欧文冊子 ● Mitsunobu Sato, Masato Okamoto, Go Ohe, Sachiko Furuichi, Hidetomo Nishikawa, Tetsuya Oshikawa, Tomoyuki Tano, SU Ahmed and Hideo Yoshida : Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal agent, in athymic nude mice bearing human salivary adenocarcinoma: Role of natural killer cells, Anticancer Research, Vol.22, No.6A, 3229-3240, 2002.

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