『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hoque MO (日) (読)
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[継承]
2. (英) Kawamaha Hitoshi (日) (読)
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[継承]
3. (英) Nakashiro Koh-ichi (日) (読)
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[継承]
4.表原 文江
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[継承]
5. (英) Hino Satoshi (日) (読)
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[継承]
6.内田 大亮
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7.原田 耕志
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8. (英) Begum NM (日) (読)
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9.吉田 秀夫
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10.佐藤 光信
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11. (英) Fujimori Takahiro (日) (読)
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題名 (必須): (英) Dysfunction of the p53 tumor suppressor pathway in head and neck cancer  (日)    [継承]
副題 (任意):
要約 (任意): (英) It is important to examine the abnormality of the entire p53 tumor suppressor pathway in head and neck cancer. We examined the mRNA expressions of p53 regulatory factors, p33ING1 and p14ARF, and a p53-target gene, p21WAF1 in head and neck cancer. Nine of 14 benign pleomorphic adenomas (PAs) and 7 of 8 malignant salivary gland tumors (MSGTs) expressed p33ING1 mRNA. Thirteen of 14 PAs expressed p14ARF mRNA, however, only 1 of 8 MSGTs expressed p14ARF mRNA. Eight of 14 PAs and 7 of 8 MSGTs expressed p21WAF1 mRNA. In salivary gland tumors, there was clear correlation between the expression of p33ING1 and p21WAF1 (p<0.0001, r2=0.53). However, there was no correlation between the expression of p14ARF and p21WAF1 (p=0.6543, r2=0.009). Twenty-six of 28 oral squamous cell carcinomas (SCCs) expressed p33ING1 mRNA. Nineteen of 28 oral SCCs expressed p14ARF mRNA. All of the oral SCCs expressed p21WAF1 mRNA. In oral SCCs, the expressions of both p33ING1 (p=0.009, r2=0.181) and p14ARF (p=0.0009, r2=0.271) correlated with the expression of p21WAF1. Interestingly, 24 of 26 oral SCCs (92%) showed either abnormality of p53 itself or loss of expression of p53 regulatory factors, p33ING or p14ARF. These results suggest that head and neck cancer often involve the dysfunction of p53 tumor suppressor pathway.  (日)    [継承]
キーワード (推奨): 1. (英) Blotting, Southern (日) (読) [継承]
2. (英) Cell Cycle Proteins (日) (読) [継承]
3. (英) Cyclin-Dependent Kinase Inhibitor p21 (日) (読) [継承]
4. (英) Cyclins (日) (読) [継承]
5. (英) DNA Primers (日) (読) [継承]
6. (英) DNA-Binding Proteins (日) (読) [継承]
7. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
8. (英) Genes, Tumor Suppressor (日) (読) [継承]
9. (英) Head and Neck Neoplasms (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Immunoenzyme Techniques (日) (読) [継承]
12. (英) Intracellular Signaling Peptides and Proteins (日) (読) [継承]
13. (英) Nuclear Proteins (日) (読) [継承]
14. (英) Prognosis (日) (読) [継承]
15. (英) Proteins (日) (読) [継承]
16. (英) RNA, Neoplasm (日) (読) [継承]
17. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
18.シグナル伝達 (signal transduction) [継承]
19. (英) Tumor Suppressor Protein p14ARF (日) (読) [継承]
20. (英) Tumor Suppressor Protein p53 (日) (読) [継承]
21. (英) Tumor Suppressor Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Oncology (International Center for Cancer Research)
(pISSN: 1019-6439, eISSN: 1791-2423)

ISSN (任意): 1019-6439
ISSN: 1019-6439 (pISSN: 1019-6439, eISSN: 1791-2423)
Title: International journal of oncology
Title(ISO): Int. J. Oncol.
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 119 126 [継承]
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年月日 (必須): 西暦 2002年 7月 初日 (平成 14年 7月 初日) [継承]
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DOI (任意):
PMID (任意): 12063558    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000176270500017 [継承]
Scopus (任意): 2-s2.0-0036654342 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Tokushima 770-8504, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● MO Hoque, Hitoshi Kawamaha, Koh-ichi Nakashiro, Fumie Omotehara, Satoshi Hino, Daisuke Uchida, Koji Harada, NM Begum, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori : Dysfunction of the p53 tumor suppressor pathway in head and neck cancer, International Journal of Oncology, Vol.21, No.1, 119-126, 2002.
欧文冊子 ● MO Hoque, Hitoshi Kawamaha, Koh-ichi Nakashiro, Fumie Omotehara, Satoshi Hino, Daisuke Uchida, Koji Harada, NM Begum, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori : Dysfunction of the p53 tumor suppressor pathway in head and neck cancer, International Journal of Oncology, Vol.21, No.1, 119-126, 2002.

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