『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.医学部 [継承]
著者 (必須): 1. (英) Li, Chei Chiun (日) (読)
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[継承]
2. (英) Xu, Bing (日) (読)
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3.廣川 満良
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4.銭 志栄
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5.吉本 勝彦
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学籍番号 (推奨):
[継承]
6.堀口 英久
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7. (英) Wakatsuki, Shingo (日) (読)
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8. (英) Tashiro, Takashi (日) (読)
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9.佐野 壽昭
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題名 (必須): (英) Alterations of E-cadherin, a-catenin and b-catenin expression in neuroendocrine tumors of the gastrointestinal tract.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Neuroendocrine tumors (NETs) of the gastrointestinal tract comprise a heterogeneous group of neoplasms arising from the diffuse neuroendocrine system. These tumors strongly differ from each other on the basis of different pathogenetic, clinical, functional, histological, and prognostic patterns. Previous studies have shown that abnormal and reduced expression of the E-cadherin/catenin complex in several human cancers is associated with tumor dedifferentiation, advanced clinical stages, and poor survival rate. We assessed correlations between the expression of E-cadherin and catenins, Ki-67, and the following clinicopathological factors: age, embryological site of origin, size, histological growth pattern, the depth of penetration into the intestinal wall, and the presence of metastasis. In this study, reduction of membranous E-cadherin expression to a variable degree was detected in more than two-thirds (42 of 51) of gastrointestinal NETs (19 foregut, 8 midgut, and 24 hindgut) belonging to the complete neuroendocrine neoplastic spectrum [18 well-differentiated NETs, 22 well-differentiated neuroendocrine carcinomas (NECs), and 11 poorly differentiated NECs]. The reduction of E-cadherin expression was concomitant with the reduction of alpha-catenin (44 of 51) and beta-catenin (35 of 51) expression. Our immunohistochemical analysis demonstrated significant differences of percentage of membranous positive cells of E-cadherin, alpha-catenin, or beta-catenin between normal tissues and well-differentiated NETs (P=0.0038, P=0.004, and P=0.0329, respectively), well-differentiated NECs (P<0.001, P<0.001, and P<0.001, respectively) and poorly differentiated NECs (P=0.0002, P<0.0002, and P=0.0002, respectively). Among the gastrointestinal NETs, there were significantly more positive cells of E-cadherin, alpha-catenin, or beta-catenin in well-differentiated NETs than well-differentiated NECs (P=0.0006, P=0.0065, and P=0.0001, respectively) or poorly differentiated NECs (P=0.0053, P=0.0041, and P<0.001, respectively). MIB-1 labeling index generally showed a low proliferative activity in well-differentiated NETs (0.49+/-0.37) and well-differentiated NECs (0.662+/-0.66). A high proliferation rate was observed in poorly differentiated NECs (41.518+/-16.59). MIB-1 labeling index was significantly higher in poorly differentiated NECs than well-differentiated NETs and well-differentiated NECs (P<0.0001 and P<0.0001, respectively). E-cadherin, alpha-catenin, and beta-catenin expression were correlated significantly with transmural tumor invasion (P<0.0001, P=0.0001, and P<0.0001, respectively) and with size (P=0.0013, P=0.0001, and P<0.0001, respectively). These results indicate that the alteration in the E-cadherin/catenin expression may be involved in the growth and progression of gastrointestinal NETs.  (日)    [継承]
キーワード (推奨): 1. (英) gastrointestinal neuroendocrine tumors (日) (読) [継承]
2. (英) E-cadherin (日) (読) [継承]
3. (英) alpha-catenin (日) (読) [継承]
4. (英) beta-catenin (日) (読) [継承]
5. (英) Ki-67 (日) (読) [継承]
6.免疫組織化学 (immunohistochemistry) [継承]
7. (英) CARCINOID-TUMORS (日) (読) [継承]
8. (英) HUMAN CANCERS (日) (読) [継承]
9. (英) PROGNOSIS (日) (読) [継承]
10. (英) PATHOGENESIS (日) (読) [継承]
11. (英) PROGRESSION (日) (読) [継承]
12.転移 (metastasis) [継承]
13.蛋白質 (protein/->キーワード[タンパク質]) [継承]
14. (英) LESIONS (日) (読) [継承]
15. (英) KI-67 (日) (読) [継承]
16. (英) APC (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Virchows Archiv (European Society of Pathology)
(pISSN: 0945-6317, eISSN: 1432-2307)

ISSN (任意): 0945-6317
ISSN: 0945-6317 (pISSN: 0945-6317, eISSN: 1432-2307)
Title: Virchows Archiv : an international journal of pathology
Title(ISO): Virchows Arch
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 440 [継承]
(必須): 2 [継承]
(必須): 145 154 [継承]
都市 (任意):
年月日 (必須): 西暦 2002年 1月 初日 (平成 14年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1007/s004280100529    (→Scopusで検索) [継承]
PMID (任意): 11964044    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-0036182725 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pathology, University of Tokushima School of Medicine, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Chiun Chei Li, Bing Xu, Mitsuyoshi Hirokawa, Zhi-Rong Qian, Katsuhiko Yoshimoto, Hidehisa Horiguchi, Shingo Wakatsuki, Takashi Tashiro and Toshiaki Sano : Alterations of E-cadherin, a-catenin and b-catenin expression in neuroendocrine tumors of the gastrointestinal tract., Virchows Archiv, Vol.440, No.2, 145-154, 2002.
欧文冊子 ● Chiun Chei Li, Bing Xu, Mitsuyoshi Hirokawa, Zhi-Rong Qian, Katsuhiko Yoshimoto, Hidehisa Horiguchi, Shingo Wakatsuki, Takashi Tashiro and Toshiaki Sano : Alterations of E-cadherin, a-catenin and b-catenin expression in neuroendocrine tumors of the gastrointestinal tract., Virchows Archiv, Vol.440, No.2, 145-154, 2002.

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