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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.歯学部.歯学科 [継承]
著者 (必須): 1. (英) Kikkawa, Yamato (日) (読)
役割 (任意): 共著 [継承]
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学籍番号 (推奨):
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2. (英) Yamanaka, Naoki (日) (読)
役割 (任意): 共著 [継承]
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3. (英) Tada, Jun (日) (読)
役割 (任意): 共著 [継承]
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4.金森 憲雄
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5.津村 恵子
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6.細井 和雄
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題名 (必須): (英) Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family ezymes (mK1, mK2, mK13, and mK22).  (日)    [継承]
副題 (任意):
要約 (任意): (英) Four members of the tissue kallikrein family, mK1, mK9, mK13, and mK22, all of which exhibit extensive homology in amino acid sequence among themselves, were obtained from the submandibular gland of ICR mice and examined for their ability to cleave prorenin. Tissue kallikrein mK13 was confirmed to be a prorenin-converting enzyme; and mK9, which was earlier shown to be an EGF-binding protein, was found to cleave mouse Ren 2 prorenin specifically and convert it to mature renin with an activity of approximately 1/10 of that of mK13. With the same substrate, mK22 (beta-NGF endopeptidase) gave two products, renin and arginyl-renin; whereas mK1 (true tissue kallikrein) did not process it at all. The endoproteolytic activity of tissue kallikreins was examined with various peptide-MCA substrates. The substrates contained three key structures; X(Y)-Arg-Arg, X(Y)-Lys-Arg and X-Lys-Lys motifs (where X and Y are hydrophilic and hydrophobic amino acids, respectively). We found that mK1, mK9 and mK13 preferentially cleaved the former two types of substrate, except Y-Arg-Arg-MCA. The substrate X-Lys-Lys-MCA was hardly cleaved by these three tissue kallikreins but was preferentially cleaved by mK22. The four tissue kallikreins seem to have the ability to process precursor proteins containing a pair of basic amino acid residues; the specificities of three of the enzymes (mK1, mK9 and mK13) were similar to each other but were different from that of mK22.  (日) マウス顎下腺に存在する4種類のカリクレイン酵素のキニン遊離活性,プロレニン変換活性を調べた.mK1は最も強いキニン遊離活性を有したがプロレニン変換活性は検出限界以下であった,他方mK13はキニン遊離活性を検出できなかったが,最も強いプロレニン変換活性をしめした.レニンアンギオテンシン系とキニンカリクレイン系がファミリーの異なるメンバーが発現することによって調節される可能性が考えられた.   [継承]
キーワード (推奨): 1. (英) Amino Acid Sequence (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Enzyme Precursors (日) (読) [継承]
4. (英) Isoenzymes (日) (読) [継承]
5. (英) Kallikreins (日) (読) [継承]
6. (英) Kinetics (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Inbred ICR (日) (読) [継承]
10. (英) Molecular Sequence Data (日) (読) [継承]
11. (英) Protein Processing, Post-Translational (日) (読) [継承]
12. (英) Renin (日) (読) [継承]
13. (英) Submandibular Gland (日) (読) [継承]
14. (英) Substrate Specificity (日) (読) [継承]
発行所 (推奨): Elsevier.Elsevier Scientific Publishing Company [継承]
誌名 (必須): Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ([Elsevier Science])
(pISSN: 0167-4838)

ISSN (任意): 0167-4838
ISSN: 0167-4838 (pISSN: 0167-4838)
Title: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
Publisher: Elsevier BV
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(必須): 55 64 [継承]
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年月日 (必須): 西暦 1998年 1月 15日 (平成 10年 1月 15日) [継承]
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DOI (任意): 10.1016/S0167-4838(97)00144-1    (→Scopusで検索) [継承]
PMID (任意): 9507064    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-0031911945 [継承]
評価値 (任意):
被引用数 (任意): 4 [継承]
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Physiology, Tokushima University School of Dentistry, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yamato Kikkawa, Naoki Yamanaka, Jun Tada, Norio Kanamori, Keiko Tsumura and Kazuo Hosoi : Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family ezymes (mK1, mK2, mK13, and mK22)., Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol.1382, No.1, 55-64, 1998.
欧文冊子 ● Yamato Kikkawa, Naoki Yamanaka, Jun Tada, Norio Kanamori, Keiko Tsumura and Kazuo Hosoi : Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family ezymes (mK1, mK2, mK13, and mK22)., Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol.1382, No.1, 55-64, 1998.

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