『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=72145EID:72145, Map:0, LastModified:2017年12月4日(月) 13:54:29, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[松本 満], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
招待 (推奨): 依頼 [継承]
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.分子酵素学研究センター (〜2007年3月31日/->組織[疾患酵素学研究センター]) [継承]
著者 (必須): 1.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting  (日)    [継承]
副題 (任意):
要約 (任意): (英) The molecular basis of lymphoid organogenesis has recently been elucidated using gene-targeted mice. Mice deficient in lymphotoxin-alpha (LT alpha) lack lymph nodes and Peyer's patches. The action of LT alpha in lymphoid organogenesis is mediated mostly by the membrane form of LT by a mechanism independent of TNF receptor I (TNFR-I) or II (TNFR-II). Additionally, follicular dendritic cell (FDC) clusters or germinal centers fail to develop in the spleen of LT alpha-deficient mice. Mice deficient in either TNFR-I or LT beta R also fail to develop splenic FDC clusters and germinal centers, indicating that signaling through both TNFR-I and LT beta R is required for the development of these structures. The mechanisms underlying the defective lymphoid organogenesis in LT alpha-deficient mice, together with a natural mutant strain, alymphoplasia (aly) mice, which manifest a quite similar phenotype to LT alpha-deficient mice, were investigated by generating aggregation chimeras. These studies demonstrate that LT alpha and the aly gene product together control lymphoid organogenesis with a close mechanistic relationship in their biochemical pathways through governing distinct cellular compartments; the former acting as a circulating ligand and the latter as a LT beta R-signaling molecule expressed by the stroma of the lymphoid organs.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, CD (日) (読) [継承]
3. (英) Gene Targeting (日) (読) [継承]
4. (英) Ligands (日) (読) [継承]
5. (英) Lymphoid Tissue (日) (読) [継承]
6. (英) Lymphotoxin-alpha (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Mice, Mutant Strains (日) (読) [継承]
9. (英) Receptors, Tumor Necrosis Factor (日) (読) [継承]
10. (英) Receptors, Tumor Necrosis Factor, Type I (日) (読) [継承]
11. (英) Receptors, Tumor Necrosis Factor, Type II (日) (読) [継承]
12. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 46 [継承]
(必須): 3,4 [継承]
(必須): 141 150 [継承]
都市 (任意):
年月日 (必須): 西暦 1999年 8月 初日 (平成 11年 8月 初日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 10687308    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
機関リポジトリ : 21957 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
3.(英) NumberOfReferences: 55  (日)    [継承]

標準的な表示

和文冊子 ● Mitsuru Matsumoto : Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting, The Journal of Medical Investigation : JMI, Vol.46, No.3,4, 141-150, Aug. 1999.
欧文冊子 ● Mitsuru Matsumoto : Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting, The Journal of Medical Investigation : JMI, Vol.46, No.3,4, 141-150, Aug. 1999.

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