『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨): 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究) [継承]
学究種別 (推奨):
組織 (推奨): 1.分子酵素学研究センター (〜2007年3月31日/->組織[疾患酵素学研究センター]) [継承]
著者 (必須): 1.松島 明美
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kaisho Tsuneyasu (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Rennert D. Paul (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Nakano Hiroyasu (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Kurosawa Kyoko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.内田 大亮
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Takeda Kiyoshi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Akira Shizuo (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9.松本 満 ([徳島大学.先端酵素学研究所.次世代酵素学研究領域])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Essential role of NF-kappaB-inducing kinase and IkappaB-kinase alpha in NF-kappaB activation through lymphotoxin-beta receptor, but not through TNF receptor-I  (日)    [継承]
副題 (任意):
要約 (任意): (英) Both nuclear factor (NF)-kappaB-inducing kinase (NIK) and inhibitor of kappaB (IkappaB) kinase (IKK) have been implicated as essential components for NF-kappaB activation in response to many external stimuli. However, the exact roles of NIK and IKKalpha in cytokine signaling still remain controversial. With the use of in vivo mouse models, rather than with enforced gene-expression systems, we have investigated the role of NIK and IKKalpha in signaling through the type I tumor necrosis factor (TNF) receptor (TNFR-I) and the lymphotoxin beta receptor (LTbetaR), a receptor essential for lymphoid organogenesis. TNF stimulation induced similar levels of phosphorylation and degradation of IkappaBalpha in embryonic fibroblasts from either wild-type or NIK-mutant mice. In contrast, LTbetaR stimulation induced NF-kappaB activation in wild-type mice, but the response was impaired in embryonic fibroblasts from NIK-mutant and IKKalpha-deficient mice. Consistent with the essential role of IKKalpha in LTbetaR signaling, we found that development of Peyer's patches was defective in IKKalpha-deficient mice. These results demonstrate that both NIK and IKKalpha are essential for the induction of NF-kappaB through LTbetaR, whereas the NIK-IKKalpha pathway is dispensable in TNFR-I signaling.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, CD (日) (読) [継承]
3. (英) Cells, Cultured (日) (読) [継承]
4. (英) DNA-Binding Proteins (日) (読) [継承]
5. (英) Fibroblasts (日) (読) [継承]
6. (英) I-kappa B Kinase (日) (読) [継承]
7. (英) I-kappa B Proteins (日) (読) [継承]
8. (英) Lymphotoxin beta Receptor (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Inbred C57BL (日) (読) [継承]
11. (英) Mice, Mutant Strains (日) (読) [継承]
12. (英) NF-kappa B (日) (読) [継承]
13. (英) Peyer's Patches (日) (読) [継承]
14. (英) Phosphorylation (日) (読) [継承]
15. (英) Protein-Serine-Threonine Kinases (日) (読) [継承]
16. (英) Receptors, Tumor Necrosis Factor (日) (読) [継承]
17. (英) Receptors, Tumor Necrosis Factor, Type I (日) (読) [継承]
18. (英) Signal Transduction (日) (読) [継承]
19. (英) Transfection (日) (読) [継承]
20. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Experimental Medicine ([The Rockefeller University Press])
(pISSN: 0022-1007, eISSN: 1540-9538)

ISSN (任意): 0022-1007
ISSN: 0022-1007 (pISSN: 0022-1007, eISSN: 1540-9538)
Title: The Journal of experimental medicine
Title(ISO): J. Exp. Med.
Publisher: Rockefeller University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 193 [継承]
(必須): 5 [継承]
(必須): 631 636 [継承]
都市 (任意):
年月日 (必須): 西暦 2001年 3月 5日 (平成 13年 3月 5日) [継承]
URL (任意):
DOI (任意): 10.1084/jem.193.5.631    (→Scopusで検索) [継承]
PMID (任意): 11238593    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000167522500009 [継承]
Scopus (任意): 2-s2.0-0035809310 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
3.(英) OtherID: PMC2193391  (日)    [継承]

標準的な表示

和文冊子 ● Akemi Matsushima, Tsuneyasu Kaisho, Paul D. Rennert, Hiroyasu Nakano, Kyoko Kurosawa, Daisuke Uchida, Kiyoshi Takeda, Shizuo Akira and Mitsuru Matsumoto : Essential role of NF-kappaB-inducing kinase and IkappaB-kinase alpha in NF-kappaB activation through lymphotoxin-beta receptor, but not through TNF receptor-I, The Journal of Experimental Medicine, Vol.193, No.5, 631-636, 2001.
欧文冊子 ● Akemi Matsushima, Tsuneyasu Kaisho, Paul D. Rennert, Hiroyasu Nakano, Kyoko Kurosawa, Daisuke Uchida, Kiyoshi Takeda, Shizuo Akira and Mitsuru Matsumoto : Essential role of NF-kappaB-inducing kinase and IkappaB-kinase alpha in NF-kappaB activation through lymphotoxin-beta receptor, but not through TNF receptor-I, The Journal of Experimental Medicine, Vol.193, No.5, 631-636, 2001.

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