『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=72037EID:72037, Map:0, LastModified:2018年12月17日(月) 16:31:57, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[吉本 勝彦], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.医学部 [継承]
著者 (必須): 1. (英) Ninomiya, Yoshihiro (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Urano, Yoshio (日) (読)
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学籍番号 (推奨):
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3.吉本 勝彦
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学籍番号 (推奨):
[継承]
4. (英) Iwahana, Hiroyuki (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Sasaki, Shiro (日) (読)
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[継承]
6.荒瀬 誠治
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学籍番号 (推奨):
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7.板倉 光夫
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学籍番号 (推奨):
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題名 (必須): (英) p53 Gene Mutation Analysis in Porokeratosis and Porokeratosis-associated Squamous Cell Carcinoma.  (日)    [継承]
副題 (任意):
要約 (任意): (英) In this and previous studies, we have shown p53 overexpression immunohistochemically in 14 of 17 porokeratotic specimens obtained from 14 lesions of nine cases, and in all six specimens of squamous cell carcinoma (SCC) arising on porokeratotic lesions of two cases. We screened mutations in exons 5 to 10 of the p53 gene in all these specimens by polymerase chain reaction-single strand conformation polymorphism analysis. Mutations of the p53 gene were detected in two of the six SCCs but not in any of the 17 porokeratotic specimens. These two mutations were C to T transitions at codons 146 and 175 in exon 5, which were a nonsense mutation at a dipyrimidine site and a missense mutation at a CG site, respectively. To our knowledge, neither of these mutations has been identified in skin cancers before. Our observations indicate that mutations of the p53 gene are not the major molecular etiology for porokeratosis, but are related to its skin carcinogenesis, and that p53 overexpression in porokeratosis is not due to p53 gene mutations.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Carcinoma, Squamous Cell (日) (読) [継承]
4. (英) DNA, Neoplasm (日) (読) [継承]
5. (英) Exons (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
8. (英) Genes, p53 (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10.免疫組織化学 (immunohistochemistry) [継承]
11. (英) Male (日) (読) [継承]
12. (英) Middle Aged (日) (読) [継承]
13. (英) Mutation (日) (読) [継承]
14. (英) Polymerase Chain Reaction (日) (読) [継承]
15. (英) Polymorphism, Single-Stranded Conformational (日) (読) [継承]
16. (英) Porokeratosis (日) (読) [継承]
17.皮膚 (skin) [継承]
18. (英) Skin Neoplasms (日) (読) [継承]
19. (英) Tumor Suppressor Protein p53 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Dermatological Science (日本研究皮膚科学会)
(pISSN: 0923-1811, eISSN: 1873-569X)

ISSN (任意): 0923-1811
ISSN: 0923-1811 (pISSN: 0923-1811, eISSN: 1873-569X)
Title: Journal of dermatological science
Title(ISO): J Dermatol Sci
Publisher: Elsevier BV
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 14 [継承]
(必須): 3 [継承]
(必須): 173 178 [継承]
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年月日 (必須): 西暦 1997年 1月 初日 (平成 9年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/S0923-1811(96)00569-5    (→Scopusで検索) [継承]
PMID (任意): 9138474    (→Scopusで検索) [継承]
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WOS (任意):
Scopus (任意): 2-s2.0-0031106755 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yoshihiro Ninomiya, Yoshio Urano, Katsuhiko Yoshimoto, Hiroyuki Iwahana, Shiro Sasaki, Seiji Arase and Mitsuo Itakura : p53 Gene Mutation Analysis in Porokeratosis and Porokeratosis-associated Squamous Cell Carcinoma., Journal of Dermatological Science, Vol.14, No.3, 173-178, 1997.
欧文冊子 ● Yoshihiro Ninomiya, Yoshio Urano, Katsuhiko Yoshimoto, Hiroyuki Iwahana, Shiro Sasaki, Seiji Arase and Mitsuo Itakura : p53 Gene Mutation Analysis in Porokeratosis and Porokeratosis-associated Squamous Cell Carcinoma., Journal of Dermatological Science, Vol.14, No.3, 173-178, 1997.

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