| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.歯学部.歯学科
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| ○著者 (必須): | 1. | (英) Oshikawa Tetsuya (日) (読)
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| 2. | 岡本 正人
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| 3. | (英) Ohe Go (日) (読)
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| 4. | (英) Furuichi Sachiko (日) (読)
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| 5. | (英) Nishikawa Hidetomo (日) (読)
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| 6. | (英) Uddin Ahmed Sharif (日) (読)
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| 7. | 吉田 秀夫
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| 8. | (英) Moriya Yoichiro (日) (読)
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| 9. | (英) Matsubara Shuzo (日) (読)
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| 10. | (英) Ryoma Yoshiki (日) (読)
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| 11. | (英) Saito Motoo (日) (読)
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| ○貢献度 (任意): |
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| 12. | 佐藤 光信
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| ○題名 (必須): | □ | (英) Anti-tumor immune response induced by the fractions derived from OK-432, a streptococcal preparation, by using a monoclonal antibody TS-2 that neutralizes the interferon-gamma-inducing activity of OK-432: comparison between the TS-2-binding and TS-2-unbinding fraction. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) We have previously isolated a lipoteichoic acid (LTA)-related molecule (OK-PSA) from OK-432, a streptococcal agent, by affinity chromatography on a CNBr-activated Sepharose 4B bound TS-2 monoclonal antibody (mAb) that neutralizes the interferon (IFN)-gamma-inducing activity of OK-432. In the current study, we compared the cytokine-inducing and anti-tumor activities of OK-PSA, a TS-2-binding fraction, with those of OK-PTF, a TS-2-unbinding fraction, in order to determine the efficacy of OK-PSA for clinical use in affinity chromatography using TS-2. In the in vitro experiments using human peripheral blood mononuclear cells (PBMCs), OK-PSA markedly induced Th1-type cytokines, while interleukin (IL)-6 and IL-10, Th2-type cytokines, were induced by OK-PTF. Th1-cytokine induction by OK-PTF was not dose-dependent and was suppressed when PBMCs were treated with a high concentration of OK-PTF. In a mouse model, Th1 cytokines were also induced by OK-PSA and Th2 cytokines were induced by OK-PTF. Th2 cytokine-inducing activity of OK-PTF was accelerated in tumor-bearing mice relative to that in healthy mice. Although the anti-tumor effect of OK-PTF was statistically significant, it was much weaker than that of OK-PSA. A significant difference between the anti-tumor effect of OK-PSA and that of OK-PTF was observed (P<0.05). Finally, OK-PSA elicited its cytokine-inducing effect via Toll-like receptor (TLR) 4, whereas OK-PTF-induced signaling was mediated by both TLR2 and TLR4. These findings strongly suggested that the affinity chromatography using TS-2 is a useful strategy to separate the effective component for cancer therapy (OK-PSA) from other components. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antibodies, Monoclonal (日) (読)
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| 3. | (英) Antibodies, Neoplasm (日) (読)
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| 4. | (英) Cells, Cultured (日) (読)
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| 5. | (英) Chromatography, Affinity (日) (読)
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| 6. | (英) Culture Media (日) (読)
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| 7. | 細胞質分裂 (cytokinesis)
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| 8. | 女性 (female)
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| 9. | (英) Humans (日) (読)
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| 10. | (英) Hybridomas (日) (読)
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| 11. | (英) In Vitro Techniques (日) (読)
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| 12. | (英) Interferon Inducers (日) (読)
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| 13. | (英) Interferon-gamma (日) (読)
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| 14. | (英) Luciferases (日) (読)
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| 15. | 男性 (male)
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| 16. | (英) Membrane Glycoproteins (日) (読)
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| 17. | (英) Mice (日) (読)
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| 18. | (英) Mice, Inbred BALB C (日) (読)
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| 19. | (英) Mice, Inbred C57BL (日) (読)
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| 20. | ノックアウトマウス (knockout mice)
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| 21. | (英) Monocytes (日) (読)
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| 22. | (英) Neoplasms (日) (読)
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| 23. | (英) Picibanil (日) (読)
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| 24. | (英) Receptors, Cell Surface (日) (読)
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| 25. | シグナル伝達 (signal transduction)
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| 26. | (英) Th1 Cells (日) (読)
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| 27. | (英) Th2 Cells (日) (読)
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| 28. | (英) Toll-Like Receptor 2 (日) (読)
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| 29. | (英) Toll-Like Receptor 4 (日) (読)
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| 30. | (英) Toll-Like Receptors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Immunopharmacology ([Elsevier])
(pISSN: 1567-5769, eISSN: 1878-1705)
| ○ISSN (任意): | □ | 1567-5769
ISSN: 1567-5769
(pISSN: 1567-5769, eISSN: 1878-1705) Title: International immunopharmacologyTitle(ISO): Int ImmunopharmacolPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 3
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 643 655
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2003年 1月 初日 (平成 15年 1月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/S1567-5769(02)00274-6 (→Scopusで検索)
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| ○PMID (任意): | □ | 12757734 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-12444250093
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Comparative Study (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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