『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=67170)

EID=67170EID:67170, Map:0, LastModified:2014年4月30日(水) 14:02:10, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[福井 清], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨): 博士課程学生による研究報告 [継承]
組織 (推奨): 1.特殊栄養学講座 (〜2004年3月31日/->組織[徳島大学.医学部.医科栄養学科.臨床実践栄養学講座.代謝栄養学]) [継承]
2.分子酵素学研究センター (〜2007年3月31日/->組織[疾患酵素学研究センター]) [継承]
3.徳島大学.医学部.医学科.感覚運動系病態医学講座 [継承]
著者 (必須): 1. (英) Li Ming (日) 李 明 (読) り みん
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Marubayashi Azusa (日) 丸林 あずさ (読) まるばやしあずさ
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.中屋 豊
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.福井 清 ([徳島大学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.荒瀬 誠治
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Minoxidil-Induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil  (日)    [継承]
副題 (任意):
要約 (任意): (英) The mechanism by which minoxidil, an adenosine-triphosphate-sensitive potassium channel opener, induces hypertrichosis remains to be elucidated. Minoxidil has been reported to stimulate the production of vascular endothelial growth factor, a possible promoter of hair growth, in cultured dermal papilla cells. The mechanism of production of vascular endothelial growth factor remains unclear, however. We hypothesize that adenosine serves as a mediator of vascular endothelial growth factor production. Minoxidil-induced increases in levels of intracellular Ca(2+) and vascular endothelial growth factor production in cultured dermal papilla cells were found to be inhibited by 8-sulfophenyl theophylline, a specific antagonist for adenosine receptors, suggesting that dermal papilla cells possess adenosine receptors and sulfonylurea receptors, the latter of which is a well-known target receptor for adenosine-triphosphate-sensitive potassium channel openers. The expression of sulfonylurea receptor 2B and of the adenosine A1, A2A, and A2B receptors was detected in dermal papilla cells by means of reverse transcription polymerase chain reaction analysis. In order to determine which of the adenosine receptor subtypes contribute to minoxidil-induced hair growth, the effects of subtype-specific antagonists for adenosine receptors were investigated. Significant inhibition in increase in intracellular calcium level by minoxidil or adenosine was observed as the result of pretreatment with 8-cyclopentyl-1,3-dipropylxanthine, an antagonist for adenosine A1 receptor, but not by 3,7-dimethyl-1-propargyl-xanthine, an antagonist for adenosine A2 receptor, whereas vascular endothelial growth factor production was blocked by both adenosine A1 and A2 receptor antagonists. These results indicate that the effect of minoxidil is mediated by adenosine, which triggers intracellular signal transduction via both adenosine A1 and A2 receptors, and that the expression of sulfonylurea receptor 2B in dermal papilla cells might play a role in the production of adenosine.  (日)    [継承]
キーワード (推奨): 1.アデノシン受容体 (adenosine receptor) [継承]
2.ATP感受性カリウムチャネル (ATP-sensitive potassium channel) [継承]
3.多毛症 (hypertrichosis) [継承]
4.細胞内カルシウム (intracellular calcium) [継承]
5.血管内皮増殖因子 (vascular endothelial growth factor) [継承]
発行所 (推奨): (英) The society for investigative Dermatology, Inc (日) (読) [継承]
誌名 (必須): The Journal of Investigative Dermatology (The Society for Investigative Dermatology)
(pISSN: 0022-202X, eISSN: 1523-1747)

ISSN (任意): 0022-202X
ISSN: 0022-202X (pISSN: 0022-202X, eISSN: 1523-1747)
Title: The Journal of investigative dermatology
Title(ISO): J. Invest. Dermatol.
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 117 [継承]
(必須): 6 [継承]
(必須): 1594 1600 [継承]
都市 (任意):
年月日 (必須): 西暦 2001年 12月 初日 (平成 13年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1046/j.0022-202x.2001.01570.x    (→Scopusで検索) [継承]
PMID (任意): 11886528    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000172903200037 [継承]
Scopus (任意): 2-s2.0-0035675210 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Ming Li, Azusa Marubayashi, Yutaka Nakaya, Kiyoshi Fukui and Seiji Arase : Minoxidil-Induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil, The Journal of Investigative Dermatology, Vol.117, No.6, 1594-1600, 2001.
欧文冊子 ● Ming Li, Azusa Marubayashi, Yutaka Nakaya, Kiyoshi Fukui and Seiji Arase : Minoxidil-Induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil, The Journal of Investigative Dermatology, Vol.117, No.6, 1594-1600, 2001.

関連情報

Number of session users = 0, LA = 2.00, Max(EID) = 360832, Max(EOID) = 966486.