『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.分子酵素学研究センター (〜2007年3月31日/->組織[疾患酵素学研究センター]) [継承]
著者 (必須): 1. (英) Yamada Takuji (日) 山田 卓司 (読) やまだ たくじ
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学籍番号 (推奨):
[継承]
2. (英) Mitani Tasuku (日) 三谷 匡 (読) みたに たすく
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3.頼田 和子
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貢献度 (任意):
学籍番号 (推奨):
[継承]
4.内田 大亮
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学籍番号 (推奨):
[継承]
5.松島 明美
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学籍番号 (推奨):
[継承]
6. (英) Iwamasa Kikue (日) (読) いわまさ きくえ
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学籍番号 (推奨):
[継承]
7. (英) Fujita Shigeru (日) 藤田 (読) ふじた しげる
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学籍番号 (推奨):
[継承]
8.松本 満 ([徳島大学.先端酵素学研究所.次世代酵素学研究領域])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-kappaB-Inducing Kinase  (日)    [継承]
副題 (任意):
要約 (任意): (英) Alymphoplasia (aly) mice, a natural strain with a mutant NF-kappa B-inducing kinase (NIK) gene, manifest a unique phenotype; they lack lymph nodes and Peyer's patches, have a disturbed spleen architecture, and exhibit defects in both Ab and cellular immune responses. Although a stromal defect caused by impaired lymphotoxin-beta receptor signaling accounts for their abnormal lymphoid organogenesis, the exact mechanisms underlying the development of immunodeficiency in aly mice are poorly understood. We therefore investigated the contribution of hemopoietic cells with the aly NIK mutation to the development of immunodeficiency. Transfer of aly/aly bone marrow cells into aly/+ mice resulted in poorly developed B cell follicles and lack of support for the development of germinal centers and isotype switching, indicating that the hemopoietic cells of aly mice contain an autonomous defect. However, follicular dendritic cell clusters were maintained in the spleens of these bone marrow chimeras, suggesting that the lack of follicular dendritic cell clusters in aly mice is probably due to the stromal defect. The aly mice lacked marginal zone B cells in their spleens, and aly/aly B cells showed an impaired proliferative response after in vitro stimulation. IL-2 production by activated T cells was also impaired. By contrast, the dendritic cells of aly mice exhibited grossly normal development and function. Supporting the concept of an autonomous cell defect, Rel protein expression was altered in aly/aly spleens. Thus, the aly NIK mutation affects hemopoietic cell function in an intrinsic fashion and, together with the stromal defect, may contribute to the development of immunodeficiency in aly mice.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) B-Lymphocytes (日) (読) [継承]
3. (英) Bone Marrow Cells (日) (読) [継承]
4. (英) Bone Marrow Transplantation (日) (読) [継承]
5. (英) Cell Differentiation (日) (読) [継承]
6. (英) Dendritic Cells (日) (読) [継承]
7. (英) Dendritic Cells, Follicular (日) (読) [継承]
8. (英) Hematopoietic Stem Cells (日) (読) [継承]
9. (英) Interleukin-2 (日) (読) [継承]
10. (英) Lymphocyte Activation (日) (読) [継承]
11. (英) Lymphopenia (日) (読) [継承]
12. (英) Mice (日) (読) [継承]
13. (英) Mice, Inbred BALB C (日) (読) [継承]
14. (英) Mice, Inbred C57BL (日) (読) [継承]
15. (英) Mice, Mutant Strains (日) (読) [継承]
16. (英) NF-kappa B (日) (読) [継承]
17. (英) Protein-Serine-Threonine Kinases (日) (読) [継承]
18. (英) Proto-Oncogene Proteins c-rel (日) (読) [継承]
19. (英) Receptors, Complement (日) (読) [継承]
20. (英) Spleen (日) (読) [継承]
21. (英) T-Lymphocytes (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J. Immunol.
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 165 [継承]
(必須): 2 [継承]
(必須): 804 812 [継承]
都市 (任意):
年月日 (必須): 西暦 2000年 7月 15日 (平成 12年 7月 15日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 10878354    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000088085600025 [継承]
Scopus (任意): 2-s2.0-0034662002 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takuji Yamada, Tasuku Mitani, Kazuko YORITA, Daisuke Uchida, Akemi Matsushima, Kikue Iwamasa, Shigeru Fujita and Mitsuru Matsumoto : Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-kappaB-Inducing Kinase, The Journal of Immunology, Vol.165, No.2, 804-812, 2000.
欧文冊子 ● Takuji Yamada, Tasuku Mitani, Kazuko YORITA, Daisuke Uchida, Akemi Matsushima, Kikue Iwamasa, Shigeru Fujita and Mitsuru Matsumoto : Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-kappaB-Inducing Kinase, The Journal of Immunology, Vol.165, No.2, 804-812, 2000.

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