『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.分子酵素学研究センター (〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター]) [継承]
著者 (必須): 1. (英) Lihong Wang (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Hayashi Hideki (日) (読) はやし ひでき
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3.岸 和弘
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学籍番号 (推奨):
[継承]
4. (英) Huang Luping (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Hagi Akifumi (日) (読) はぎ あきふみ
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学籍番号 (推奨):
[継承]
6. (英) Tamaoka Keisuke (日) (読) たまおか けいすけ
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学籍番号 (推奨):
[継承]
7. (英) Hawkins T Phillip (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
8.蛯名 洋介
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Activation of phosphoinositide 3-kinase (PI-3K) is essential for insulin-stimulated translocation of GLUT4 and glucose transport in insulin target tissues. A novel p110gamma PI-3K was reported to be activated by G(i)-coupled receptors via Gbetagamma subunits. We asked whether the stimulation of G(i)-coupled receptors would trigger GLUT4 translocation and glucose uptake by the activation of Gbetagamma-dependent p110gamma PI-3K. We find that this translocation and glucose uptake can be induced by the ligand stimulation of G(i)-coupled alpha(2A) adrenergic receptor and fMet-Leu-Phe receptor in cells stably expressing these receptors. The noradrenaline ('noradrenaline')- and fMet-Leu-Phe-stimulated GLUT4 translocations were abolished by pretreatment with pertussis toxin. Pretreatment with wortmannin or genistein also inhibited the G(i)-mediated GLUT4 translocation. On ligand stimulation of these two kinds of G(i)-coupled receptor, although there was a slight increase in PtdIns(3,4,5)P(3) production, activation of either the p85/p110alpha PI-3K or Gbetagamma-dependent p110gamma PI-3K was not observed even in Chinese hamster ovary cells stably overexpressing exogenous p101/p110gamma. The G(i)-mediated GLUT4 translocation was accompanied by activation of the serine-threonine kinase Akt; the inhibitory effects of pertussis toxin, wortmannin and genistein on G(i)-mediated GLUT4 translocation paralleled their inhibitory effects on Akt activation. In contrast, the activation of some other G(i)-coupled receptors, such as prostaglandin EP3alpha receptor and platelet-activating factor receptor, did not cause either pertussis-toxin-sensitive translocation of GLUT4myc or activation of Akt kinase. These results indicate that the ligand stimulation of some G(i)-coupled receptors triggers GLUT4 translocation that occurs independently of p85/p110alpha-type and p110gamma-type PI-3Ks but might involve the activation of Akt kinase.  (日)    [継承]
キーワード (推奨): 1. (英) Adrenergic alpha-Agonists (日) (読) [継承]
2. (英) Amino Acid Sequence (日) (読) [継承]
3. (英) Androstadienes (日) (読) [継承]
4. (英) Animals (日) (読) [継承]
5. (英) Biological Transport (日) (読) [継承]
6. (英) CHO Cells (日) (読) [継承]
7. (英) Cricetinae (日) (読) [継承]
8. (英) Enzyme Activation (日) (読) [継承]
9. (英) Enzyme Inhibitors (日) (読) [継承]
10. (英) GTP-Binding Protein alpha Subunits, Gi-Go (日) (読) [継承]
11. (英) Genes, myc (日) (読) [継承]
12. (英) Genistein (日) (読) [継承]
13.グルコース (glucose) [継承]
14. (英) Glucose Transporter Type 4 (日) (読) [継承]
15. (英) Molecular Sequence Data (日) (読) [継承]
16. (英) Monosaccharide Transport Proteins (日) (読) [継承]
17. (英) Muscle Proteins (日) (読) [継承]
18. (英) N-Formylmethionine Leucyl-Phenylalanine (日) (読) [継承]
19. (英) Norepinephrine (日) (読) [継承]
20. (英) Pertussis Toxin (日) (読) [継承]
21. (英) Phorbol 12,13-Dibutyrate (日) (読) [継承]
22. (英) Phosphatidylinositol 3-Kinases (日) (読) [継承]
23. (英) Phosphatidylinositol Phosphates (日) (読) [継承]
24. (英) Platelet Membrane Glycoproteins (日) (読) [継承]
25. (英) Protein-Serine-Threonine Kinases (日) (読) [継承]
26. (英) Proto-Oncogene Proteins (日) (読) [継承]
27. (英) Proto-Oncogene Proteins c-akt (日) (読) [継承]
28. (英) Receptors, Adrenergic, alpha-2 (日) (読) [継承]
29. (英) Receptors, Cell Surface (日) (読) [継承]
30. (英) Receptors, Formyl Peptide (日) (読) [継承]
31. (英) Receptors, G-Protein-Coupled (日) (読) [継承]
32. (英) Receptors, Immunologic (日) (読) [継承]
33. (英) Receptors, Peptide (日) (読) [継承]
34. (英) Receptors, Prostaglandin E (日) (読) [継承]
35. (英) Virulence Factors, Bordetella (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Biochemical Journal ([The Biochemical Society])
(pISSN: 0264-6021, eISSN: 1470-8728)

ISSN (任意): 0264-6021
ISSN: 0264-6021 (pISSN: 0264-6021, eISSN: 1470-8728)
Title: The Biochemical journal
Title(ISO): Biochem J
Publisher: Portland Press, Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 345 [継承]
(必須): Pt 3 [継承]
(必須): 543 555 [継承]
都市 (任意):
年月日 (必須): 西暦 2000年 2月 1日 (平成 12年 2月 1日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 10642513    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Molecular Genetics, Institute for Enzyme Research, University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC1220789  (日)    [継承]

標準的な表示

和文冊子 ● Wang Lihong, Hideki Hayashi, Kazuhiro Kishi, Luping Huang, Akifumi Hagi, Keisuke Tamaoka, Phillip T Hawkins and Yousuke Ebina : Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase., The Biochemical Journal, Vol.345, No.Pt 3, 543-555, 2000.
欧文冊子 ● Wang Lihong, Hideki Hayashi, Kazuhiro Kishi, Luping Huang, Akifumi Hagi, Keisuke Tamaoka, Phillip T Hawkins and Yousuke Ebina : Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase., The Biochemical Journal, Vol.345, No.Pt 3, 543-555, 2000.

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