| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 高石 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学]/[徳島大学.病院.診療科.歯科口腔外科.歯科麻酔科]/[徳島大学.歯学部.歯学科.口腔疾患系臨床歯学講座.歯科麻酔科学])
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| 2. | (英) Kinoshita Hiroyuki (日) (読)
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| 3. | (英) Feng Guo-Gang (日) (読)
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| 4. | (英) Azma Toshiharu (日) (読)
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| 5. | 川人 伸次 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学])
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| 6. | 北畑 洋
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| ○題名 (必須): | □ | (英) Cytoskeleton-disrupting agent cytochalasin B reduces oxidative stress caused by high glucose in the human arterial smooth muscle (日)
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| ○要約 (任意): | □ | (英) The role of cytoskeleton dynamics in the oxidative stress toward human vasculature has been unclear. The current study examined whether the cytoskeleton-disrupting agent cytochalasin B reduces oxidative stress caused by high glucose in the human arterial smooth muscle. All experiments in the human omental arteries without endothelium or the cultured human coronary artery smooth muscle cells were performed in d-glucose (5.5 mmol/L). The exposure toward d-glucose (20 mmol/L) for 60 min reduced the relaxation or hyperpolarization to an ATP sensitive K channel (KATP) opener levcromakalim (10 to 3 × 10 mol/L and 3 × 10 mol/L, respectively). Cytochalasin B and a superoxide inhibitor Tiron, restored them similarly. Cytochalasin B reduced the NADPH oxidase activity, leading to a decrease in superoxide levels of the arteries treated with high d-glucose. Also, cytochalasin B impaired the F-actin constitution and the membrane translocation of an NADPH oxidase subunit p47phox in artery smooth muscle cells treated with high d-glucose. A clinical concentration of cytochalasin B prevented human vascular smooth muscle malfunction via the oxidative stress caused by high glucose. Regulation of the cytoskeleton may be essential to keep the normal vascular function in patients with hyperglycemia. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Cells, Cultured (日) (読)
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| 4. | (英) Cromakalim (日) (読)
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| 5. | (英) Cytochalasin B (日) (読)
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| 6. | (英) Cytoskeleton (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Glucose (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | (英) Hyperglycemia (日) (読)
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| 11. | (英) In Vitro Techniques (日) (読)
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| 12. | (英) Male (日) (読)
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| 13. | (英) Middle Aged (日) (読)
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| 14. | (英) Muscle Relaxation (日) (読)
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| 15. | (英) Muscle, Smooth, Vascular (日) (読)
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| 16. | (英) Myocytes, Smooth Muscle (日) (読)
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| 17. | (英) NADPH Oxidases (日) (読)
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| 18. | (英) Oxidative Stress (日) (読)
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| 19. | (英) Superoxides (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Pharmacological Sciences ([日本薬理学会])
(pISSN: 1347-8613, eISSN: 1347-8648)
| ○ISSN (任意): | □ | 1347-8648
ISSN: 1347-8613
(pISSN: 1347-8613, eISSN: 1347-8648) Title: Journal of pharmacological sciencesTitle(ISO): J Pharmacol SciSupplier: 公益社団法人 日本薬理学会Publisher: Japanese Pharmacological Society (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 144
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 197 203
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| ○年月日 (必須): | □ | 西暦 2020年 12月 初日 (令和 2年 12月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.jphs.2020.08.004 (→Scopusで検索)
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| ○PMID (任意): | □ | 33070838 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.jphs.2020.08.004 (日)
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| 2. | (英) Article.ELocationID: S1347-8613(20)30088-8 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Cytoskeleton (日)
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| 5. | (英) KeywordList.Keyword: Glucose (日)
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| 6. | (英) KeywordList.Keyword: Human (日)
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| 7. | (英) KeywordList.Keyword: Oxidative stress (日)
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| 8. | (英) KeywordList.Keyword: Vascular smooth muscle (日)
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| 9. | (英) CoiStatement: Declaration of competing interest None. (日)
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