| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Nishida H (日) (読)
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| 2. | (英) Albero AB (日) (読)
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| 3. | (英) Onoue K (日) (読)
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| 4. | (英) Ikegawa Y (日) (読)
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| 5. | (英) Sulekh S (日) (読)
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| 6. | (英) Sakizli U (日) (読)
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| 7. | (英) Minami Y (日) (読)
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| 8. | 米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
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| 9. | (英) Wang YC (日) (読)
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| 10. | (英) Yoo SK (日) (読)
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| ○題名 (必須): | □ | (英) Necrosensor: a genetically encoded fluorescent sensor for visualizing necrosis in Drosophila. (日)
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| ○要約 (任意): | □ | (英) Historically, necrosis has been considered a passive process, which is induced by extreme stress or damage. However, recent findings of necroptosis, a programmed form of necrosis, shed a new light on necrosis. It has been challenging to detect necrosis reliably in vivo, partly due to the lack of genetically encoded sensors to detect necrosis. This is in stark contrast with the availability of many genetically encoded biosensors for apoptosis. Here we developed Necrosensor, a genetically encoded fluorescent sensor that detects necrosis in Drosophila, by utilizing HMGB1, which is released from the nucleus as a damage-associated molecular pattern (DAMP). We demonstrate that Necrosensor is able to detect necrosis induced by various stresses in multiple tissues in both live and fixed conditions. Necrosensor also detects physiological necrosis that occurs during spermatogenesis in the testis. Using Necrosensor, we discovered previously unidentified, physiological necrosis of hemocyte progenitors in the hematopoietic lymph gland of developing larvae. This work provides a new transgenic system that enables in vivo detection of necrosis in real time without any intervention. (日)
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| ○キーワード (推奨): | 1. | (英) Male (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Drosophila (日) (読)
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| 4. | (英) Necrosis (日) (読)
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| 5. | (英) Apoptosis (日) (読)
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| 6. | (英) Biosensing Techniques (日) (読)
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| 7. | (英) Spermatogenesis (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biology Open ([The Company of Biologists Limited])
(eISSN: 2046-6390)
| ○ISSN (任意): | □ | 2046-6390
ISSN: 2046-6390
(eISSN: 2046-6390) Title: Biology openTitle(ISO): Biol OpenPublisher: Company of Biologists (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 13
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | bio060104 bio060104
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| ○年月日 (必須): | □ | 西暦 2023年 12月 21日 (令和 5年 12月 21日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1242/bio.060104 (→Scopusで検索)
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| ○PMID (任意): | □ | 38156558 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: bio060104 (日)
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| 2. | (英) Article.ELocationID: 10.1242/bio.060104 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Drosophila (日)
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| 5. | (英) KeywordList.Keyword: In vivo (日)
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| 6. | (英) KeywordList.Keyword: Cell death (日)
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| 7. | (英) KeywordList.Keyword: Necrosis (日)
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| 8. | (英) KeywordList.Keyword: Necrosis sensor (日)
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| 9. | (英) CoiStatement: Competing interests The authors declare no competing or financial interests. (日)
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