| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 友成 哲
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| ○学籍番号 (推奨): | □ | ****
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| 2. | (英) Tani Joji (日) (読)
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| 3. | 佐藤 康史 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域消化器・総合内科学])
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| 4. | 田中 宏典 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.消化器内科])
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 田中 貴大
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| ○学籍番号 (推奨): | □ | ****
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| 6. | 谷口 達哉
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| ○学籍番号 (推奨): | □ | ****
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| 7. | 河野 豊
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| 8. | (英) Morishita Asahiro (日) (読)
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| 9. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 10. | 曽我部 正弘 ([徳島大学.キャンパスライフ健康支援センター])
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| ○学籍番号 (推奨): | □ | ****
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| 11. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 12. | (英) Masaki Tsutomu (日) (読)
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| 13. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) Clinical Features and Outcomes of Conversion Therapy in Patients with Unresectable Hepatocellular Carcinoma. (日)
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| ○要約 (任意): | □ | (英) (日) <jats:p>This retrospective multicenter study analyzed 244 patients with unresectable hepatocellular carcinoma treated with lenvatinib (LEN) and atezolizumab + bevacizumab (Atezo + Bev) to examine the characteristics, treatment courses, and prognoses. The cases of patients who could achieve HCC downstaging from Barcelona Clinic Liver Cancer (BCLC) stage B or C to A or zero indicated the need for conversion therapy. The patients' prognoses with and without conversion therapy were compared. Of the 244 patients, 12 (4.9%) underwent conversion therapy, six out of 131 (4.6%) were treated with LEN, and six out of 113 (5.3%) were treated with Atezo + Bev. Eleven patients (91.7%) with a modified albumin bilirubin (mALBI) grade 1 or 2a and BCLC-B stage showed significantly higher rates of transition during conversion therapy (p < 0.05). The patients undergoing conversion therapy had a significantly longer median overall survival rate than those receiving chemotherapy alone (1208 [1064–NA] vs. 569 [466–704] days, p < 0.01). A comparison of the patients who achieved a partial response with and without conversion was evaluated using propensity score matching to reduce the confounding factors, showing a significant survival benefit in the conversion group (1208 [1064–NA] vs. 665 days, p < 0.01). Among the patients with u-HCC who were treated with LEN and Atezo + Bev, those with mALBI 1 + 2a and BCLC-B were likely to achieve conversion therapy with downstaging.</jats:p>
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| ○キーワード (推奨): |
| ○発行所 (推奨): | □ | (英) MDPI AG (日) (読)
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| ○誌名 (必須): | □ | Cancers (Basel)
(eISSN: 2072-6694)
| ○ISSN (任意): | □ | 2072-6694
ISSN: 2072-6694
(eISSN: 2072-6694) Title: CancersTitle(ISO): Cancers (Basel)Publisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 15
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| ○号 (必須): | □ | 21
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| ○頁 (必須): | □ | 5221 5221
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| ○年月日 (必須): | □ | 西暦 2023年 10月 30日 (令和 5年 10月 30日)
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| ○URL (任意): | □ | https://www.mdpi.com/2072-6694/15/21/5221
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| ○DOI (任意): | □ | 10.3390/cancers15215221 (→Scopusで検索)
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| ○PMID (任意): |
| ○CRID (任意): | □ | 1360580235903920000
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| ○Scopus (任意): | 1. | 2-s2.0-85176601973
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