| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yokoyama Reiko (日) 横山 怜子 (読) よこやま れいこ
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 佐藤 康史 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域消化器・総合内科学])
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| 3. | 中村 文香
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| 4. | 影本 開三 ([徳島大学.病院.中央診療施設等.がん診療連携センター])
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| 5. | 三井 康裕 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| 6. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 7. | 河野 豊 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| 8. | 曽我部 正弘 ([徳島大学.キャンパスライフ健康支援センター])
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| ○学籍番号 (推奨): | □ | ****
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| 9. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 10. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) Efficacy of immune checkpoint inhibitors in patients with anorectal melanoma in association with immune-related adverse events: a case series. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Anorectal melanoma (AM) is a rare subtype of mucosal melanoma with a poor prognosis. Given its rarity compared to its cutaneous counterpart, the benefits and side effects of immune checkpoint inhibitor (ICI) therapy and the relationship between side effects and prognosis remain unclear. Herein, we describe the clinical presentation of five patients with AM treated with ICI as well as their relationship to the treatment course and the development of immune-related adverse events (irAEs). Three patients received sequential or concurrent administrations of nivolumab and ipilimumab, one received nivolumab alone, and one received ipilimumab alone. The response rate (RR) and disease control rate (DCR) were 40% and 80%, respectively. Pituitary and hepatic dysfunctions were the most common irAEs observed (40% each), followed by thyroid, diarrhea, and renal dysfunctions (20% each). The RR was 67% in patients with irAEs while no response was observed in patients without irAEs. DCR was 100% and 50% in patients with and without irAEs, respectively. Overall survival was 34 months in irAE and 8.75 months in non-irAE cases, with a longer survival trend in irAE cases. ICI therapy was effective and well-tolerated by AM patients, with potentially better outcomes for those who experienced irAEs compared to those who did not. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Clinical Journal of Gastroenterology ([財団法人 日本消化器病学会])
(pISSN: 1865-7257, eISSN: 1865-7265)
| ○ISSN (任意): | □ | 1865-7265
ISSN: 1865-7257
(pISSN: 1865-7257, eISSN: 1865-7265) Title: Clinical journal of gastroenterologyTitle(ISO): Clin J GastroenterolPublisher: Springer (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | Online ahead of print.
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ |
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2023年 8月 26日 (令和 5年 8月 26日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s12328-023-01849-z (→Scopusで検索)
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| ○PMID (任意): | □ | 37632658 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85169147432
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s12328-023-01849-z (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Anorectal melanoma (日)
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| 4. | (英) KeywordList.Keyword: Immune checkpoint inhibitors (日)
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| 5. | (英) KeywordList.Keyword: Immune-related adverse events (日)
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| 6. | (英) KeywordList.Keyword: Ipilimumab (日)
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| 7. | (英) KeywordList.Keyword: Nivolumab (日)
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