『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=399147)

EID=399147EID:399147, Map:0, LastModified:2023年9月21日(木) 10:23:20, Operator:[新見 優子], Avail:TRUE, Censor:0, Owner:[浪花 耕平], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1.浪花 耕平 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.総合診療歯科学])
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[継承]
2. (英) Hirose Katsutoshi (日) (読)
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[継承]
3. (英) Usami Yu (日) (読)
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[継承]
4. (英) Hata Kenji (日) (読)
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[継承]
5. (英) Araki Rikita (日) (読)
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[継承]
6. (英) Uzawa Narikazu (日) (読)
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[継承]
7. (英) Komori Toshihisa (日) (読)
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[継承]
8. (英) Toyosawa Satoru (日) (読)
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[継承]
題名 (必須): (英) Fam20C overexpression in odontoblasts regulates dentin formation and odontoblast differentiation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) FAM20C phosphorylates secretory proteins at S-x-E/pS motifs, and previous studies of Fam20C-dificient mice revealed that FAM20C played essential roles in bone and tooth formation. Inactivation of FAM20C in mice led to hypophosphatemia that masks direct effect of FAM20C in these tissues, and consequently the direct role of FAM20C remains unknown. Our previous study reported that osteoblast/odontoblast-specific Fam20C transgenic (Fam20C-Tg) mice had normal serum phosphate levels and that osteoblastic FAM20C-mediated phosphorylation regulated bone formation and resorption. Here, we investigated the direct role of FAM20C in dentin using Fam20C-Tg mice. The tooth of Fam20C-Tg mice contained numerous highly phosphorylated proteins, including SIBLINGs, compared to that of wild-type mice. In Fam20C-Tg mice, coronal dentin volume decreased and mineral density unchanged at early age, while the volume unchanged and the mineral density elevated at maturity. In these mice, radicular dentin volume and mineral density decreased at all ages, and histologically, the radicular dentin had wider predentin and abnormal apical-side dentin with embedded cells and argyrophilic canaliculi. Immunohistochemical analyses revealed that abnormal apical-side dentin had bone and dentin matrix properties accompanied with osteoblast-lineage cells. Further, in Fam20C-Tg mice, DSPP content which is important for dentin formation, was reduced in dentin, especially radicular dentin, which might lead to defects mainly in radicular dentin. Renal subcapsular transplantations of tooth germ revealed that newly formed radicular dentin replicated apical abnormal dentin of Fam20C-Tg mice, corroborating that FAM20C overexpression indeed caused the abnormal dentin. Our findings indicate that odontoblastic FAM20C-mediated phosphorylation in the tooth regulates dentin formation and odontoblast differentiation.  (日)    [継承]
キーワード (推奨): 1. (英) Mice (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Odontoblasts (日) (読) [継承]
4. (英) Mice, Transgenic (日) (読) [継承]
5. (英) Tooth (日) (読) [継承]
6. (英) Cell Differentiation (日) (読) [継承]
7. (英) Extracellular Matrix Proteins (日) (読) [継承]
8. (英) Dentin (日) (読) [継承]
9. (英) Phosphoproteins (日) (読) [継承]
10. (英) Calcium-Binding Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Molecular Histology ([Springer-Verlag])
(pISSN: 1567-2379, eISSN: 1567-2387)

ISSN (任意): 1567-2387
ISSN: 1567-2379 (pISSN: 1567-2379, eISSN: 1567-2387)
Title: Journal of molecular histology
Title(ISO): J Mol Histol
Supplier: Kluwer Online
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 54 [継承]
(必須): 4 [継承]
(必須): 329 347 [継承]
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年月日 (必須): 西暦 2023年 6月 26日 (令和 5年 6月 26日) [継承]
URL (任意):
DOI (任意): 10.1007/s10735-023-10123-y    (→Scopusで検索) [継承]
PMID (任意): 37357253    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85162896363 [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kohei Naniwa, Katsutoshi Hirose, Yu Usami, Kenji Hata, Rikita Araki, Narikazu Uzawa, Toshihisa Komori and Satoru Toyosawa : Fam20C overexpression in odontoblasts regulates dentin formation and odontoblast differentiation., Journal of Molecular Histology, Vol.54, No.4, 329-347, 2023.
欧文冊子 ● Kohei Naniwa, Katsutoshi Hirose, Yu Usami, Kenji Hata, Rikita Araki, Narikazu Uzawa, Toshihisa Komori and Satoru Toyosawa : Fam20C overexpression in odontoblasts regulates dentin formation and odontoblast differentiation., Journal of Molecular Histology, Vol.54, No.4, 329-347, 2023.

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