『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=396711EID:396711, Map:0, LastModified:2024年8月19日(月) 13:28:34, Operator:[西岡 安彦], Avail:TRUE, Censor:承認済, Owner:[西岡 安彦], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
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○著者 (必須): 1. (英) Nguyen Na T (日) (読)
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○学籍番号 (推奨): □**** [ユーザ]
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2.三橋 惇志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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3.荻野 広和 ([徳島大学.病院.診療科.内科.呼吸器・膠原病内科])
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4.香西 博之
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5.米田 浩人
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6. (英) Afroj Tania (日) (読)
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7.佐藤 正大 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学]/[徳島大学.病院.診療科.内科.呼吸器・膠原病内科])
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8.軒原 浩
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9.篠原 勉 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域呼吸器・総合内科学])
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10.西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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○題名 (必須): □(英) S-1 eliminates MDSCs and enhances the efficacy of PD-1 blockade via regulation of tumor-derived Bv8 and S100A8 in thoracic tumor.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Myeloid-derived suppressor cells (MDSCs) have been known to play a pivotal role in the induction of immune tolerance, which limits the benefits of immune checkpoint inhibitors (ICIs). Recent studies revealed that several chemotherapeutic agents decreased tumor-infiltrating MDSCs. Therefore, combination therapy with cytotoxic chemotherapeutic agents and ICIs was approved for first-line treatment for lung cancer. However, the impact of chemotherapeutic agents on MDSCs and an optimal partner of ICIs has not been fully investigated in thoracic tumors, including lung cancer and malignant pleural mesothelioma. In the present study, we found that treatment with 5-FU and its oral formulation, S-1, suppressed tumor progression and inhibited the accumulation of MDSCs in thoracic tumor-bearing mice. Tumor-infiltrating T cells and dendritic cells were significantly expanded in S-1-treated mice. 5-FU suppressed the ability of tumor cells to recruit MDSCs, while it did not suppress the survival and differentiation of mouse MDSCs in vitro. We also revealed that 5-FU or S-1 significantly downregulated the expression of tumor-derived Bv8 and S100A8. The knockdown of Bv8 or S100A8 in tumor cells suppressed tumor growth and MDSC recruitment in vivo. Furthermore, in comparison with pemetrexed, administration of S-1 improved the synergistic therapeutic efficacy of anti-PD-1 antibodies with or without carboplatin. Our findings revealed a novel mechanism wherein S-1 primed a favorable tumor microenvironment to provide the rationale for combination therapy with S-1 and ICIs as the optimal therapy for thoracic cancer.  (日)    [継承]
○キーワード (推奨): 1. (英) Mice (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Myeloid-Derived Suppressor Cells (日) (読) [継承]
4. (英) Calgranulin A (日) (読) [継承]
5.Tリンパ球 (T lymphocytes) [継承]
6. (英) Thoracic Neoplasms (日) (読) [継承]
7. (英) Lung Neoplasms (日) (読) [継承]
8. (英) Tumor Microenvironment (日) (読) [継承]
9. (英) Cell Line, Tumor (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Cancer Science ([日本癌学会])
(pISSN: 1347-9032, eISSN: 1349-7006)

○ISSN (任意): □1349-7006
ISSN: 1347-9032 (pISSN: 1347-9032, eISSN: 1349-7006)
Title: Cancer science
Title(ISO): Cancer Sci
Publisher: Wiley-Blackwell
 (NLM Catalog)   (医中誌Web)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □114 [継承]
○号 (必須): □2 [継承]
○頁 (必須): □384 398 [継承]
○都市 (任意):
○年月日 (必須): □西暦 2023年 2月 初日 (令和 5年 2月 初日) [継承]
○URL (任意):
○DOI (任意): □10.1111/cas.15620    (→Scopusで検索) [継承]
○PMID (任意): □36285504    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● T Na Nguyen, Atsushi Mitsuhashi, Hirokazu Ogino, Hiroyuki Kozai, Hiroto Yoneda, Tania Afroj, Seidai Satou, Hiroshi Nokihara, Tsutomu Shinohara and Yasuhiko Nishioka : S-1 eliminates MDSCs and enhances the efficacy of PD-1 blockade via regulation of tumor-derived Bv8 and S100A8 in thoracic tumor., Cancer Science, 114, 2, 384-398, 2023.
欧文冊子 ● T Na Nguyen, Atsushi Mitsuhashi, Hirokazu Ogino, Hiroyuki Kozai, Hiroto Yoneda, Tania Afroj, Seidai Satou, Hiroshi Nokihara, Tsutomu Shinohara and Yasuhiko Nishioka : S-1 eliminates MDSCs and enhances the efficacy of PD-1 blockade via regulation of tumor-derived Bv8 and S100A8 in thoracic tumor., Cancer Science, 114, 2, 384-398, 2023.

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