| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 友成 哲
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 田中 宏典 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.内科.消化器内科])
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| ○学籍番号 (推奨): | □ | ****
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| 3. | 田中 貴大
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| ○学籍番号 (推奨): | □ | ****
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| 4. | 谷口 達哉
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 曽我部 正弘 ([徳島大学.キャンパスライフ健康支援センター])
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| 6. | 河野 豊 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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| 7. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 8. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 9. | 佐藤 康史 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域消化器・総合内科学])
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| 10. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) A case of complete response with rechallenge-lenvatinib plus transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma refractory to multiple molecular-targeted agent treatments. (日)
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| ○要約 (任意): | □ | (英) The efficacy of lenvatinib (LEN) plus transcatheter arterial chemoembolization (LEN-TACE) has been reported, but its effect on unresectable hepatocellular carcinoma (HCC) refractory to LEN therapy has not been demonstrated. We report a case of HCC refractory to multiple molecular-targeted agents (MTA) treatments, including LEN, that was successfully treated with LEN-TACE. A 59-year-old man was referred to our department with multiple HCCs and a background of hepatitis B virus infection. TACE was the initial treatment. However, he was determined to be TACE-refractory, and multitargeted therapy was initiated. LEN was started at 12 mg/day but resulted in progressive disease (PD) after 13 months of the administration. The response to second-line sorafenib was PD after 2 months. Third-line therapy with atezolizumab + bevacizumab was stopped after one course because of an immune-related adverse event (i.e., dermatitis). The response to fourth-line regorafenib was PD at 2 months, and the response to fifth-line cabozantinib was PD after 6 months. The efficacy of LEN-TACE was recently reported; therefore, we decided to attempt LEN-TACE therapy as a salvage line. After obtaining the patient's consent to repeat LEN and TACE, treatment was initiated. The tumor markers levels markedly reduced after LEN-TACE therapy. After three additional TACE treatments with continued LEN administration, the tumor marker levels normalized, and complete response was determined based on RECIST guidelines. LEN-TACE therapy may effectively treat unresectable advanced HCC in the LEN-rechallenge setting and may be a treatment option as a last-line therapeutic option. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Clinical Journal of Gastroenterology ([財団法人 日本消化器病学会])
(pISSN: 1865-7257, eISSN: 1865-7265)
| ○ISSN (任意): | □ | 1865-7265
ISSN: 1865-7257
(pISSN: 1865-7257, eISSN: 1865-7265) Title: Clinical journal of gastroenterologyTitle(ISO): Clin J GastroenterolPublisher: Springer (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 16
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 438 443
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2023年 3月 1日 (令和 5年 3月 1日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s12328-023-01777-y (→Scopusで検索)
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| ○PMID (任意): | □ | 36856957 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s12328-023-01777-y (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Hepatocellular carcinoma (日)
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| 4. | (英) KeywordList.Keyword: LEN-TACE (日)
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| 5. | (英) KeywordList.Keyword: Lenvatinib (日)
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