| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○学究種別 (推奨): |
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| ○著者 (必須): | 1. | 喜田 慶史 ([徳島大学.大学院医歯薬学研究部.医学域.先端臨床医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 岡久 稔也 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域総合医療学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 3. | 佐藤 康史 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域消化器・総合内科学])
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| 4. | 板東 正浩 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○学籍番号 (推奨): | □ | ****
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| 5. | (英) Fujimoto Shota (日) 藤本 将太 (読) ふじもと しょうた
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| ○学籍番号 (推奨): | □ | ****
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| 6. | (英) beibei ma (日) 馬 貝貝 (読) ま べいべい
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| ○学籍番号 (推奨): | □ | ****
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| 7. | 中川 忠彦
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| ○学籍番号 (推奨): | □ | ****
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| 8. | 川口 智之 ([徳島大学.病院.診療科.内科.消化器内科])
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| ○学籍番号 (推奨): | □ | ****
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| 9. | 中村 文香
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| ○学籍番号 (推奨): | □ | ****
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| 10. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 11. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 12. | 曽我部 正弘 ([徳島大学.キャンパスライフ健康支援センター])
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| 13. | 常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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| 14. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) Urokinase-type plasminogen activator blockade ameliorates experimental colitis in mice. (日)
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| ○要約 (任意): | □ | (英) Although several angiogenesis-related factors are reportedly involved in the pathogenesis of ulcerative colitis (UC), the mechanisms by which they contribute to disease are unclear. We first examined the expression of angiogenesis-related factors in inflamed colorectal tissue of UC patients using antibody array, and identified the 5 factors with highest expression, which included matrix metalloproteinase-8, urokinase-type plasminogen activator (uPA), angiostatin/plasminogen, hepatocyte growth factor and endoglin. Subsequent real-time PCR experiments using additional colorectal tissues revealed that uPA mRNA levels were significantly higher in inflamed tissues than in non-inflamed tissues, and significantly correlated with the severity of UC. Mirror section immunohistochemistry revealed that uPA was expressed in the neutrophils of inflamed colorectal tissues. We administered dextran sulfate sodium (DSS) in drinking water to uPA knockout (uPA) mice, and found that the disease activity index in uPA mice was marginally lower and the histological score in uPA mice was significantly lower than those in wild-type mice, suggesting the importance of uPA in colitis. When an uPA-selective inhibitor, UK122, was administered to DSS-treated C57BL6J mice, the disease activity index and histological score in those mice were significantly lower compared with control mice. Multiple cytokine/chemokine assay using colorectal tissues from uPA and UK122-treated mice revealed significantly lowered level of RANTES. In conclusion, uPA was highly expressed in neutrophils of the inflamed mucosa of UC patients, and the expression level correlated with the severity of UC. Genetic uPA deletion or pharmacological uPA blockade significantly ameliorated colitis in mice, concomitant with downregulation of RANTES. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Mice (日) (読)
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| 3. | (英) Urokinase-Type Plasminogen Activator (日) (読)
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| 4. | (英) Colitis (日) (読)
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| 5. | (英) Colitis, Ulcerative (日) (読)
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| 6. | (英) Serine Proteases (日) (読)
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| 7. | (英) Colorectal Neoplasms (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Scientific Reports ([Nature Publishing Group])
(eISSN: 2045-2322)
| ○ISSN (任意): | □ | 2045-2322
ISSN: 2045-2322
(eISSN: 2045-2322) Title: Scientific reportsTitle(ISO): Sci RepPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 13
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 2899 2899
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| ○年月日 (必須): | □ | 西暦 2023年 2月 18日 (令和 5年 2月 18日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/s41598-023-29824-1 (→Scopusで検索)
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| ○PMID (任意): | □ | 36806262 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 2899 (日)
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| 2. | (英) Article.ELocationID: 10.1038/s41598-023-29824-1 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) CoiStatement: The authors declare no competing interests. (日)
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