| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○組織 (推奨): | 1. | 徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学 (2015年4月1日〜)
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| ○著者 (必須): | 1. | 常松 貴明 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| 2. | 新垣 理恵子
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| 3. | (英) Satoh Mami (日) 佐藤 真美 (読) さとう まみ
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 4. | 齋藤 雅子
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| 5. | 大塚 邦紘 ([徳島大学.病院.先端歯科医療開発研究プロジェクト]/[徳島大学.病院.診療科.歯科口腔外科.口腔外科])
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| 6. | (英) Yusuke Furukawa (日) (読)
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| 7. | (英) Yuhji Taquahashi (日) (読)
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| 8. | (英) Jun Kanno (日) (読)
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| 9. | 石丸 直澄 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| ○題名 (必須): | □ | (英) Exposure to Multiwall Carbon Nanotubes Promotes Fibrous Proliferation by Production of Matrix Metalloproteinase-12 via NF-κB Activation in Chronic Peritonitis. (日)
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| ○要約 (任意): | □ | (英) The toxicologic effects of nanomaterials, such as carbon nanotubes (CNTs), on the immune system are considerably understood. However, the precise relationship between long-term exposure to CNTs and chronic inflammation remains unclear. In this study, a mouse model of chronic peritonitis was established using i.p. injection of multiwalled CNTs treated by the Taquann method with high dispersion efficiency. Chronic peritonitis with fibrosis was observed in Taquann-treated multiwalled CNT (T-CNT)-injected mice, but not in Taquann-treated titanium dioxide-injected mice. In vivo and in vitro experiments showed that matrix metalloproteinase-12 (MMP-12) of macrophages was up-regulated by T-CNT to enhance fibroblast activation and profibrotic molecule expression in fibroblasts. In addition, T-CNT-induced peritonitis reduced MMP-12 expression in Nfκb1 mice, suggesting that MMP-12-producing macrophages play a key role in chronic inflammation due to T-CNT exposure through NF-κB activation. The results of this study could be helpful in understanding the molecular toxicity of nanomaterial and chronic inflammation. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The American Journal of Pathology ([American Society for Investigative Pathology])
(pISSN: 0002-9440, eISSN: 1525-2191)
| ○ISSN (任意): | □ | 1525-2191
ISSN: 0002-9440
(pISSN: 0002-9440, eISSN: 1525-2191) Title: The American journal of pathologyTitle(ISO): Am J PatholPublisher: American Society for Investigative Pathology (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | S0002-9440
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| ○号 (必須): | □ | 22
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| ○頁 (必須): | □ | 00240 00240
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 8月 10日 (令和 4年 8月 10日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.ajpath.2022.07.009 (→Scopusで検索)
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| ○PMID (任意): | □ | 35963465 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S0002-9440(22)00240-1 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.ajpath.2022.07.009 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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