| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Shono Kenji (日) (読)
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| 2. | 溝渕 佳史
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| 3. | 山口 泉 ([徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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| 4. | 中島 公平 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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| 5. | (英) Fujiwara Yuri (日) (読)
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| 6. | 藤原 敏孝 ([徳島大学.病院.中央診療施設等.てんかんセンター])
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| 7. | (英) Kitazato Keiko (日) (読)
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| 8. | 松﨑 和仁
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| 9. | 宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命コース])
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| 10. | (英) Sampetrean Oltea (日) (読)
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| 11. | (英) Saya Hideyuki (日) (読)
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| 12. | 髙木 康志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| ○題名 (必須): | □ | (英) Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Glioblastoma (GBM) has high mortality rates because of extreme therapeutic resistance. During surgical resection for GBM, 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is conventionally applied to distinguish GBM. However, surgical intervention is insufficient for high invasive GBM. Sonodynamic therapy (SDT) combined with low-intensity ultrasonication (US) and PpIX, as a sonosensitizer, is an emerging and promising approach, although its efficacy is limited. Based on our previous study that down-regulation of multidrug resistant protein (MDR1) in GBM augmented the anti-tumor effects of chemotherapy, we hypothesized that elevation of cellular PpIX levels by down-regulation of MDR1 enhances anti-tumor effects by SDT. In high invasive progeny cells from mouse glioma stem cells (GSCs) and a GSC-bearing mouse glioma model, we assessed the anti-tumor effects of SDT with a COX-2 inhibitor, celecoxib. Down-regulation of MDR1 by celecoxib increased cellular PpIX levels, as well as valspodar, an MDR1 inhibitor, and augmented anti-tumor effects of SDT. MDR1 down-regulation via the Akt/NF-κB pathway by celecoxib was confirmed, using an NF-κB inhibitor, CAPÉ. Thus, elevation of cellar PpIX by down-regulation of MDR1 via the Akt/NF-κB pathway may be crucial to potentiate the efficacy of SDT in a site-directed manner and provide a promising new therapeutic strategy for GBM. (日)
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| ○キーワード (推奨): | 1. | (英) ATP Binding Cassette Transporter, Subfamily B, Member 1 (日) (読)
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| 2. | (英) Aminolevulinic Acid (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Cell Line, Tumor (日) (読)
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| 5. | (英) Down-Regulation (日) (読)
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| 6. | (英) Glioblastoma (日) (読)
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| 7. | (英) Glioma (日) (読)
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| 8. | (英) Male (日) (読)
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| 9. | (英) Mice (日) (読)
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| 10. | (英) Mice, Inbred C57BL (日) (読)
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| 11. | (英) NF-kappa B (日) (読)
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| 12. | (英) Neoplastic Stem Cells (日) (読)
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| 13. | (英) Photosensitizing Agents (日) (読)
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| 14. | (英) Proto-Oncogene Proteins c-akt (日) (読)
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| 15. | (英) Protoporphyrins (日) (読)
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| 16. | (英) Signal Transduction (日) (読)
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| 17. | (英) Ultrasonic Therapy (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Scientific Reports ([Nature Publishing Group])
(eISSN: 2045-2322)
| ○ISSN (任意): | □ | 2045-2322
ISSN: 2045-2322
(eISSN: 2045-2322) Title: Scientific reportsTitle(ISO): Sci RepPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ | 1
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| ○頁 (必須): |
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| ○年月日 (必須): | □ | 西暦 2021年 7月 23日 (令和 3年 7月 23日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/s41598-021-93896-0 (→Scopusで検索)
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| ○PMID (任意): | □ | 34301977 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Research Support, Non-U.S. Gov't (日)
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