| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): | □ | 博士後期課程学生による研究報告
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| ○組織 (推奨): | 1. | 徳島大学.大学院社会産業理工学研究部 (2017年4月1日〜)
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| ○著者 (必須): | 1. | (英) Nishimoto Hiroaki (日) 西本 浩章 (読) にしもと ひろあき
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 福田 昇司
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| 3. | (英) Fukui Naoshi (日) 福井 尚志 (読) ふくい なおし
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| 4. | 西良 浩一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.運動機能外科学])
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| 5. | 山口 鉄生 ([徳島大学.大学院社会産業理工学研究部.社会総合科学域.人間科学系.スポーツ健康分野]/[徳島大学.総合科学部.社会総合科学科.心身健康コース])
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| ○題名 (必須): | □ | (英) Characteristics of gene expression in frozen shoulder (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Severe frozen shoulder (FS) is often resistant to treatment and can thus result in long-term functional impairment. However, its etiology remains unknown. We hypothesized that gene expression of FS would vary by synovial location. The synovial tissues of patients with FS were collected prospectively and analyzed for the expression of 19 genes. Synovial tissues from patients with rotator cuff tear (RCT) or shoulder instability (SI) were also analyzed as controls. A total of 10 samples were analyzed from each group. The specimens were arthroscopically taken from three different locations: rotator interval (RI), axillary recess (AX), and subacromial bursa (SAB). Total RNA was extracted from the collected tissues and was analyzed by real-time polymerase chain reaction for the following genes: matrix metalloproteinases (MMPs); tissue inhibitors of metalloproteinases (TIMPs); inflammatory cytokines (IL1B, TNF, and IL6); type I and II procollagen (COL1A1 and COL2A1); growth factors (IGF1 and TGFB1); neural factors (NGF and NGFR); SOX9; and ACTA2. Site-specific analysis showed that MMP13, IL-6, SOX9, and COL1A1 were increased in all three sites. Four genes (MMP3, MMP9, COL2A1, and NGFR) were increased in the AX, MMP3 in the RI, and NGFR in the SAB were increased in the FS group than in the RCT and SI groups. In the FS group, there was a correlation between the expression of genes related to chondrogenesis (MMP2, IGF1, SOX9, COL2A1, NGF, and NGFR) or fibrosis (MMP9, TGFB1, and COL1A1). The expression levels of numerous MMPs, pro-inflammatory cytokines, and collagen-related genes were increased in the FS group, suggesting that catabolic and anabolic changes have simultaneously occurred. In addition, genes related to chondrogenesis or fibrosis were highly expressed in the FS group, which might have affected the range of motion limitation of the shoulder. Compared to RI and SAB, the AX was the most common site of increased expression in FS. Analyzing the lower region of the shoulder joint may lead to the elucidation of the pathogenesis of FS. (日)
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| ○キーワード (推奨): | 1. | (英) frozen shoulder (日) (読)
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| 2. | (英) gene expression (日) (読)
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| 3. | (英) fibrosis (日) (読)
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| 4. | (英) chondrogenesis (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | BMC Musculoskeletal Disorders ([BioMed Central Ltd.])
(eISSN: 1471-2474)
| ○ISSN (任意): | □ | 1471-2474
ISSN: 1471-2474
(eISSN: 1471-2474) Title: BMC musculoskeletal disordersTitle(ISO): BMC Musculoskelet DisordPublisher: BioMed Central (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 23
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 811 811
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 8月 25日 (令和 4年 8月 25日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1186/s12891-022-05762-3 (→Scopusで検索)
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| ○PMID (任意): | □ | 36008780 (→Scopusで検索)
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| ○指導教員 (推奨): | 1. | 山口 鉄生 ([徳島大学.大学院社会産業理工学研究部.社会総合科学域.人間科学系.スポーツ健康分野]/[徳島大学.総合科学部.社会総合科学科.心身健康コース])
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1186/s12891-022-05762-3 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Chondrogenesis (日)
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| 4. | (英) KeywordList.Keyword: Fibrosis (日)
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| 5. | (英) KeywordList.Keyword: Frozen shoulder (日)
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| 6. | (英) KeywordList.Keyword: Gene expression (日)
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