| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Tsushima Fumihiko (日) 津島 文彦 (読) つしま ふみひこ
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| 2. | (英) Sakurai Jinkyo (日) 櫻井 仁亨 (読) さくらい じんきょう
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| 3. | 上杉 篤史 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])
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| 4. | (英) Oikawa Yu (日) 及川 悠 (読) おいかわ ゆう
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| 5. | (英) Ohsako Toshimitu (日) 大迫 利光 (読) おおさこ としみつ
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| 6. | (英) Mochizuki Yumi (日) 望月 裕美 (読) もちづき ゆみ
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| 7. | (英) Hirai Hideaki (日) 平井 秀明 (読) ひらい ひであき
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| 8. | (英) Kayamori Kou (日) 柏森 高 (読) かやもり こう
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| 9. | (英) Harada Hiroyuki (日) 原田 浩之 (読) はらだ ひろゆき
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| ○題名 (必須): | □ | (英) Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients (日)
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| ○要約 (任意): | □ | (英) Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear. We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions, oral lichenoid drug reactions and oral lichenoid lesions of graft-versus-host disease were excluded. The study population included 123 men and 442 women aged 21-93 years (mean ± standard deviation, 60.5 ± 11.8). The 565 patients were followed up for a duration of 55.9 ± 45.3 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type. Our results suggested that OLP was associated with a low risk of malignant transformation. We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia and OLLs to enable early detection of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary. (日)
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| ○キーワード (推奨): | 1. | 癌 (cancer)
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| 2. | (英) Oral mucosal disease (日) 口腔粘膜疾患 (読) こうくうねんまくしっかん
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | BMC Oral Health ([BioMed Central Ltd.])
(eISSN: 1472-6831)
| ○ISSN (任意): | □ | 1472-6831
ISSN: 1472-6831
(eISSN: 1472-6831) Title: BMC oral healthTitle(ISO): BMC Oral HealthPublisher: BioMed Central (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 21
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 298 298
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2021年 6月 10日 (令和 3年 6月 10日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1186/s12903-021-01652-7 (→Scopusで検索)
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| ○PMID (任意): | □ | 34112142 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1186/s12903-021-01652-7 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Malignant transformation (日)
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| 4. | (英) KeywordList.Keyword: Oral lichen planus (日)
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| 5. | (英) KeywordList.Keyword: Oral squamous cell carcinoma (日)
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| 6. | (英) KeywordList.Keyword: Retrospective study (日)
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