| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 佐藤 真美 ([徳島大学.病院.診療科.歯科口腔外科.口腔内科]/[徳島大学.病院.先端歯科医療開発研究プロジェクト]/->個人[福場 真美])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | 新垣 理恵子
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 3. | (英) Tawara Hiroaki (日) (読)
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| ○学籍番号 (推奨): |
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| 4. | 常松 貴明 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | 石丸 直澄
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| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Formation of Autoimmune Lesions Is Independent of Antibiotic Treatment in NOD Mice. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The relationship between autoimmunity and changes in intestinal microbiota is not yet fully understood. In this study, the role of intestinal microbiota in the onset and progression of autoimmune lesions in non-obese diabetic (NOD) mice was evaluated by administering antibiotics to alter their intestinal microenvironment. Flow cytometric analysis of spleen cells showed that antibiotic administration did not change the proportion or number of T and B cells in NOD mice, and pathological analysis demonstrated that autoimmune lesions in the salivary glands and in the pancreas were also not affected by antibiotic administration. These results suggest that the onset and progression of autoimmunity may be independent of enteral microbiota changes. Our findings may be useful for determining the appropriate use of antibiotics in patients with autoimmune diseases who are prescribed drugs to maintain systemic immune function. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Anti-Bacterial Agents (日) (読)
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| 3. | (英) Autoimmune Diseases (日) (読)
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| 4. | 自己免疫 (autoimmunity)
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| 5. | 細胞質分裂 (cytokinesis)
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| 6. | (英) Disease Models, Animal (日) (読)
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| 7. | (英) Disease Susceptibility (日) (読)
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| 8. | (英) Immune System (日) (読)
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| 9. | (英) Mice (日) (読)
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| 10. | (英) Mice, Inbred NOD (日) (読)
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| 11. | (英) Sialadenitis (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Journal of Molecular Sciences (Molecular Diversity Preservation International/Multidisciplinary Digital Publishing Institute)
(pISSN: 1661-6596, eISSN: 1422-0067)
| ○ISSN (任意): | □ | 1422-0067
ISSN: 1661-6596
(pISSN: 1661-6596, eISSN: 1422-0067) Title: International journal of molecular sciencesTitle(ISO): Int J Mol SciPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 22
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 3239 3239
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2021年 3月 22日 (令和 3年 3月 22日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/ijms22063239 (→Scopusで検索)
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| ○PMID (任意): | □ | 33810172 (→Scopusで検索)
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| ○CRID (任意): |
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 3239 (日)
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| 2. | (英) Article.ELocationID: 10.3390/ijms22063239 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: NOD mice (日)
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| 5. | (英) KeywordList.Keyword: Sjögren's syndrome (日)
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| 6. | (英) KeywordList.Keyword: antibiotic treatment (日)
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| 7. | (英) KeywordList.Keyword: autoimmune lesion (日)
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| 8. | (英) KeywordList.Keyword: type 1 diabetes (日)
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