| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない))
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| ○学究種別 (推奨): | □ | 博士課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Wada Akihiro (日) 和田 明大 (読) わだ あきひろ
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 2. | 村上 圭史
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Ishikawa Yumi (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 天羽 崇
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 平尾 功治
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 細川 由樹 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | 日野出 大輔 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健衛生学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | 三宅 洋一郎
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | 湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Anti-Inflammatory and Protective Effects of Juncus effusus L. Water Extract on Oral Keratinocytes (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Periodontitis is a chronic inflammatory disease caused by periodontopathogenic bacteria that form biofilms in periodontal pockets. The gingival epithelium acts as the first physical barrier in fighting attacks by periodontopathogenic pathogens, such as the primary etiological agent , and various exogenous chemicals, as well as regulates the local innate immune responses. Therefore, the development of novel oral care products to inhibit inflammatory reactions caused by bacterial infection and protect the gingival epithelium is necessary. L. has generally been used as an indigenous medicine, such as a diuretic, an antipyretic, and an analgesic, in ancient practice. In this study, we examined the effects of a water extract from L. on the inhibition of the inflammatory reaction elicited by bacterial infection and protection of the oral epithelium by chemical irritation. Pretreatment of oral epithelial cells with the water extract from L. significantly reduced or its lipopolysaccharide- (LPS-) mediated production of chemokines (interleukin-8 and C-C-chemokine ligand20) in a concentration-dependent manner with comparable to or greater effects than epigallocatechin gallate and protected oral epithelial cells from injury by chemical irritants, cetylpyridinium chloride, and benzethonium chloride. Moreover, the water extract from . L. in the presence of antimicrobial agents or antifibrinolytics already used as ingredients in mouthwash could significantly reduce the production of chemokines from LPS-stimulated oral epithelial cells in a concentration-dependent manner. These findings suggest that the water extract from . L. is potentially useful for oral care to prevent oral infections, such as periodontal infections, and maintain oral epithelial function. (日)
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| ○キーワード (推奨): | 1. | (英) Anti-Inflammatory Agents (日) (読)
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| 2. | (英) Bacteroidaceae Infections (日) (読)
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| 3. | (英) Cell Line, Transformed (日) (読)
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| 4. | (英) Humans (日) (読)
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| 5. | (英) Keratinocytes (日) (読)
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| 6. | (英) Magnoliopsida (日) (読)
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| 7. | (英) Mouth Mucosa (日) (読)
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| 8. | (英) Periodontitis (日) (読)
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| 9. | (英) Plant Extracts (日) (読)
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| 10. | (英) Porphyromonas gingivalis (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | BioMed Research International (Hindawi Pub. Co.)
(pISSN: 2314-6133, eISSN: 2314-6141)
| ○ISSN (任意): | □ | 2314-6141
ISSN: 2314-6133
(pISSN: 2314-6133, eISSN: 2314-6141) Title: BioMed research internationalTitle(ISO): Biomed Res IntPublisher: Hindawi (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 2022
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| ○号 (必須): |
| ○頁 (必須): | □ | 9770899 9770899
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 1月 4日 (令和 4年 1月 4日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1155/2022/9770899 (→Scopusで検索)
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| ○PMID (任意): | □ | 35028318 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85123567270
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): | 1. | 湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1155/2022/9770899 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) CoiStatement: The authors have no conflicts of interest to declare. (日)
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