| ○種別 (必須): | □ | 総説·解説
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 佐藤 康史 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域消化器・総合内科学])
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| 2. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 3. | 川口 智之 ([徳島大学.病院.診療科.内科.消化器内科])
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| 4. | 中村 文香
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| 5. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 6. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) Treatment Response Predictors of Neoadjuvant Therapy for Locally Advanced Gastric Cancer: Current Status and Future Perspectives. (日)
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| ○要約 (任意): | □ | (英) Neoadjuvant chemotherapy (NAC) for locally advanced gastric cancer (LAGC) has been recognized as an effective therapeutic option because it is expected to improve the curative resection rate by reducing the tumor size and preventing recurrence of micrometastases. However, for patients resistant to NAC, not only will operation timing be delayed, but they will also suffer from side effects. Thus, it is crucial to develop a comprehensive strategy and select patients sensitive to NAC. However, the therapeutic effect of NAC is unpredictable due to tumor heterogeneity and a lack of predictive biomarkers for guiding the choice of optimal preoperative treatment in clinical practice. This article summarizes the related research progress on predictive biomarkers of NAC for gastric cancer. Among the many investigated biomarkers, metabolic enzymes for cytotoxic agents, nucleotide excision repair, and microsatellite instability, have shown promising results and should be assessed in prospective clinical trials. Noninvasive liquid biopsy detection, including miRNA and exosome detection, is also a promising strategy. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Biomedicines (MDPI AG)
(eISSN: 2227-9059)
| ○ISSN (任意): | □ | 2227-9059
ISSN: 2227-9059
(eISSN: 2227-9059) Title: BiomedicinesTitle(ISO): BiomedicinesPublisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 10
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| ○号 (必須): | □ | 7
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| ○頁 (必須): | □ | 1614 1614
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| ○年月日 (必須): | □ | 西暦 2022年 7月 6日 (令和 4年 7月 6日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3390/biomedicines10071614 (→Scopusで検索)
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| ○PMID (任意): | □ | 35884916 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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| 2. | (英) PublicationType: Review (日)
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