| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Mori M (日) (読)
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| 2. | (英) Yao T (日) (読)
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| 3. | (英) Mishina T (日) (読)
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| 4. | (英) Endoh H (日) (読)
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| 5. | (英) Tanaka M (日) (読)
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| 6. | (英) Yonezawa N (日) (読)
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| 7. | (英) Shimamoto Y (日) (読)
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| 8. | 米村 重信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.細胞生物学])
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| 9. | (英) Yamagata K (日) (読)
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| 10. | (英) Kitajima TS (日) (読)
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| 11. | (英) Ikawa M (日) (読)
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| ○題名 (必須): | □ | (英) RanGTP and the actin cytoskeleton keep paternal and maternal chromosomes apart during fertilization. (日)
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| ○要約 (任意): | □ | (英) Zygotes require two accurate sets of parental chromosomes, one each from the mother and the father, to undergo normal embryogenesis. However, upon egg-sperm fusion in vertebrates, the zygote has three sets of chromosomes, one from the sperm and two from the egg. The zygote therefore eliminates one set of maternal chromosomes (but not the paternal chromosomes) into the polar body through meiosis, but how the paternal chromosomes are protected from maternal meiosis has been unclear. Here we report that RanGTP and F-actin dynamics prevent egg-sperm fusion in proximity to maternal chromosomes. RanGTP prevents the localization of Juno and CD9, egg membrane proteins that mediate sperm fusion, at the cell surface in proximity to maternal chromosomes. Following egg-sperm fusion, F-actin keeps paternal chromosomes away from maternal chromosomes. Disruption of these mechanisms causes the elimination of paternal chromosomes during maternal meiosis. This study reveals a novel critical mechanism that prevents aneuploidy in zygotes. (日)
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| ○キーワード (推奨): | 1. | (英) Actin Cytoskeleton (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Cells, Cultured (日) (読)
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| 4. | (英) Chromosomes (日) (読)
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| 5. | (英) Female (日) (読)
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| 6. | (英) Fertilization (日) (読)
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| 7. | (英) Humans (日) (読)
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| 8. | (英) Mice (日) (読)
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| 9. | (英) Mice, Inbred Strains (日) (読)
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| 10. | (英) ran GTP-Binding Protein (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Cell Biology (Rockefeller Institute/American Society for Cell Biology)
(pISSN: 0021-9525, eISSN: 1540-8140)
| ○ISSN (任意): | □ | 1540-8140
ISSN: 0021-9525
(pISSN: 0021-9525, eISSN: 1540-8140) Title: The Journal of cell biologyTitle(ISO): J Cell BiolPublisher: Rockefeller University Press (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 220
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| ○号 (必須): | □ | 10
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| ○頁 (必須): | □ |
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2021年 10月 4日 (令和 3年 10月 4日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1083/jcb.202012001 (→Scopusで検索)
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| ○PMID (任意): | □ | 34424312 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: e202012001 (日)
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| 2. | (英) Article.ELocationID: 10.1083/jcb.202012001 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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