| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 佐光 亘
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| 2. | (英) Abe T (日) (読)
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| 3. | (英) Matsumoto Y (日) (読)
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| 4. | (英) Nakamura K (日) (読)
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| 5. | 土師 正太郎
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| 6. | 大崎 裕亮 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床神経科学]/[徳島大学.病院.診療科.内科.脳神経内科])
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| 7. | 原田 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学])
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| 8. | 和泉 唯信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床神経科学]/[徳島大学.病院.診療科.内科.脳神経内科])
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| ○題名 (必須): | □ | (英) The cerebellum is a common key for visuospatial execution and attention in Parkinson's disease (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Cognitive decline affects the clinical course in patients with Parkinson's disease (PD) and contributes to a poor prognosis. However, little is known about the underlying network-level abnormalities associated with each cognitive domain. We aimed to identify the networks related to each cognitive domain in PD using resting-state functional magnetic resonance imaging (MRI). Forty patients with PD and 15 normal controls were enrolled. All subjects underwent MRI and the Mini-Mental State Examination. Furthermore, the cognitive function of patients with PD was assessed using the Montreal Cognitive Assessment (MoCA). We used independent component analysis of the resting-state functional MRI for functional segmentation, followed by reconstruction to identify each domain-related network, to predict scores in PD using multiple regression models. Six networks were identified, as follows: the visuospatial-executive-domain-related network ( = 0.54, < 0.001), naming-domain-related network ( = 0.39, < 0.001), attention-domain-related network ( = 0.86, < 0.001), language-domain-related network ( = 0.64, < 0.001), abstraction-related network ( = 0.10, < 0.05), and orientation-domain-related network ( = 0.64, < 0.001). Cerebellar lobule VII was involved in the visuospatial-executive-domain-related and attention-domain-related networks. These two domains are involved in the first three listed nonamnestic cognitive impairment in the diagnostic criteria for PD with dementia (PDD). Furthermore, Brodmann area 10 contributed most frequently to each domain-related network. Collectively, these findings suggest that cerebellar lobule VII may play a key role in cognitive impairment in nonamnestic types of PDD. (日)
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| ○キーワード (推奨): | 1. | (英) (日) Parkinson's disease (読)
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| 2. | (英) cognition (日) (読)
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| 3. | (英) functional MRI (日) (読)
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| 4. | (英) network (日) (読)
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| 5. | (英) cerebellum (日) (読)
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| ○発行所 (推奨): | □ | (英) MDPI (日) (読)
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| ○誌名 (必須): | □ | Diagnostics (MDPI AG)
(eISSN: 2075-4418)
| ○ISSN (任意): | □ | 2075-4418
ISSN: 2075-4418
(eISSN: 2075-4418) Title: Diagnostics (Basel, Switzerland)Title(ISO): Diagnostics (Basel)Publisher: Multidisciplinary Digital Publishing Institute (MDPI) (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 1042 1042
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2021年 6月 6日 (令和 3年 6月 6日)
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| ○URL (任意): | □ | http://repo.lib.tokushima-u.ac.jp/116520
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| ○DOI (任意): | □ | 10.3390/diagnostics11061042 (→Scopusで検索)
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| ○PMID (任意): | □ | 34204073 (→Scopusで検索)
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| ○CRID (任意): | □ | 1050021072400356992
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| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85108274727
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 1042 (日)
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| 2. | (英) Article.ELocationID: 10.3390/diagnostics11061042 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Parkinson's disease (日)
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| 5. | (英) KeywordList.Keyword: cerebellum (日)
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| 6. | (英) KeywordList.Keyword: cognition (日)
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| 7. | (英) KeywordList.Keyword: functional MRI (日)
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| 8. | (英) KeywordList.Keyword: network (日)
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| 9. | (英) CoiStatement: The authors declare that they have no conflict of interest. (日)
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