『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=385757EID:385757, Map:0, LastModified:2022年6月23日(木) 13:55:03, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[髙木 康志], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Yamaguchi Tadashi (日) 山口 真司 (読) やまぐち ただし
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学籍番号 (推奨): **** [ユーザ]
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2.宮本 健志 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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3. (英) Shikata Eiji (日) 四方 英二 (読) しかた えいじ
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4.山口 泉
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5.島田 健司 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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6. (英) Yagi Kenji (日) 八木 謙次 (読) やぎ けんじ
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7.多田 恵曜 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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8.高麗 雅章 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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9. (英) Kitazato T. Keiko (日) 北里 慶子 (読)
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10.兼松 康久
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11.髙木 康志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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題名 (必須): (英) Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats  (日)    [継承]
副題 (任意):
要約 (任意): (英) Subarachnoid hemorrhage (SAH) due to intracranial aneurysm (IA) rupture is often a devastating event. Since the incidence of SAH increases especially in menopause, it is crucial to clarify the detailed pathogenesis of these events. The activation of vascular nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes has been studied in ischemic stroke and cardiovascular disease. However, the role of NLRP3 in IA rupture still needs to be explained. The authors sought to test their hypothesis that, under estrogen-deficient conditions, activation of NLRP3 inflammasomes via downregulation of the estrogen receptor (ER) facilitates IA rupture. Ten-week-old female Sprague Dawley rats with and without oophorectomy were subjected to hemodynamic changes and hypertension (OVX+/HT and OVX-/HT, respectively) and fed a high-salt diet. Separately, using human brain endothelial cells (HBECs) and human brain smooth muscle cells (HBSMCs), the authors tested the effect of NLRP3 under estrogen-free conditions and in the presence of estradiol or of ER agonists. In OVX+/HT rats, the frequency of IA rupture was significantly higher than in OVX-/HT rats (p = 0.03). In the left posterior cerebral artery prone to rupture in OVX+/HT rats, the levels of the mRNAs encoding ERα and Sirt1, but not of that encoding ERβ, were decreased, and the levels of the mRNAs encoding NLRP3, interleukin-1β (IL-1β), and matrix metalloproteinase 9 (MMP-9) were elevated. Immunohistochemical analysis demonstrated that the expression profiles of these proteins correlated with their mRNA levels. Treatment with an ER modulator, bazedoxifene, normalized the expression profiles of these proteins and improved SAH-free survival. In HBECs and HBSMCs under estrogen-free conditions, the depletion of ERα and Sirt1 and the accumulation of NLRP3 were counteracted by exposure to estradiol or to an ERα agonist but not to an ERβ agonist. To the authors' knowledge, this work represents the first demonstration that, in an aneurysm model under estrogen-deficient conditions, the depletion of ERα and Sirt1 may contribute to activation of the NLRP3/IL-1β/MMP-9 pathway, facilitating the rupture of IAs in the estrogen-deficient rat IA rupture model.  (日)    [継承]
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誌名 (必須): Journal of Neurosurgery (American Association of Neurological Surgeons/Harvey Cushing Society)
(pISSN: 0022-3085, eISSN: 1933-0693)

ISSN (任意): 1933-0693
ISSN: 0022-3085 (pISSN: 0022-3085, eISSN: 1933-0693)
Title: Journal of neurosurgery
Title(ISO): J Neurosurg
Publisher: American Association of Neurological Surgeons
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年月日 (必須): 西暦 2022年 5月 20日 (令和 4年 5月 20日) [継承]
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DOI (任意): 10.3171/2022.4.JNS212945    (→Scopusで検索) [継承]
PMID (任意): 35594890    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.3171/2022.4.JNS212945  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: NLRP3 inflammasome  (日)    [継承]
4.(英) KeywordList.Keyword: Sirt1  (日)    [継承]
5.(英) KeywordList.Keyword: estrogen deficiency  (日)    [継承]
6.(英) KeywordList.Keyword: estrogen receptor  (日)    [継承]
7.(英) KeywordList.Keyword: intracranial aneurysm  (日)    [継承]
8.(英) KeywordList.Keyword: vascular disorders  (日)    [継承]

標準的な表示

和文冊子 ● Tadashi Yamaguchi, Takeshi Miyamoto, Eiji Shikata, Izumi Yamaguchi, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Masaaki Korai, Keiko T. Kitazato, Yasuhisa Kanematsu and Yasushi Takagi : Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats, Journal of Neurosurgery, 1-8, 2022.
欧文冊子 ● Tadashi Yamaguchi, Takeshi Miyamoto, Eiji Shikata, Izumi Yamaguchi, Kenji Shimada, Kenji Yagi, Yoshiteru Tada, Masaaki Korai, Keiko T. Kitazato, Yasuhisa Kanematsu and Yasushi Takagi : Activation of the NLRP3/IL-1β/MMP-9 pathway and intracranial aneurysm rupture associated with the depletion of ERα and Sirt1 in oophorectomized rats, Journal of Neurosurgery, 1-8, 2022.

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