| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 中村 文香
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 佐藤 康史 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域消化器・総合内科学])
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| 3. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 4. | 藤野 泰輝
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 三井 康裕 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○学籍番号 (推奨): | □ | ****
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| 6. | (英) kagemoto kaizo (日) 影本 開三 (読) かげもと かいぞう
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| ○学籍番号 (推奨): | □ | ****
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| 7. | 川口 智之 ([徳島大学.病院.診療科.内科.消化器内科])
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| ○学籍番号 (推奨): | □ | ****
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| 8. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| ○学籍番号 (推奨): |
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| 9. | 六車 直樹
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| 10. | (英) Sonoda Tomoko (日) (読)
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| [継承] |
| 11. | 常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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| 12. | 高山 哲治 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学])
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| ○題名 (必須): | □ | (英) Colorectal carcinoma occurring via the adenoma-carcinoma pathway in patients with serrated polyposis syndrome. (日)
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| ○要約 (任意): | □ | (英) Although serrated polyposis syndrome (SPS) is associated with an increased colorectal cancer (CRC) risk, the carcinogenic mechanisms remain unknown. We investigated clinicopathological characteristics and genetic abnormalities in colorectal polyps and CRC to elucidate carcinogenic mechanisms in SPS. We retrospectively analyzed clinicopathological features of colorectal polyps in 44 SPS patients, and examined mutations of genes including APC, RAS, BRAF, and TP53, and microsatellite instability (MSI) in CRC tissues. Of the 44 patients, 25 (56%) fulfilled WHO criterion 1, 11 (25%) fulfilled criterion 2, and 8 (18%) fulfilled both. A total of 956 polyps were observed; 642 (67%) hyperplastic polyps (HP), 204 (21%) sessile serrated lesions (SSL), 10 (1%) traditional serrated adenoma (TSA), and 100 (11%) adenomas. The median numbers of polyps (/patient) were 10.5 (IQR 2.75-23) HPs, 4.0 (2.0-6.0) SSLs, 0 (0-0) TSA, and 1 (0-3.3) adenoma. SSL and HP located preferentially in the proximal and distal colon, respectively. Twenty-two CRCs were found in 18 patients. Based on the histological coexistence of SSL/TSA, BRAF mutation and MSI, 5 CRCs (26%) were classified as serrated-neoplasia pathway. Conversely, based on the coexistence of adenoma, APC/RAS and TP53 mutations, 11 CRCs (58%) were classified as adenoma-carcinoma pathway. The remaining three were unclassifiable. Most CRCs through adenoma-carcinoma pathway were located in the left-side colorectum and patients bearing those met criterion 2, characterized by many HP and advanced adenomas. Adenoma was a significant risk factor for CRC. Our results suggest that more than half of the CRCs, particularly those in the left-side colorectum, developed through the adenoma-carcinoma pathway in SPS patients. Adenoma was a risk factor for CRCs, suggesting its importance in colorectal carcinogenesis. (日)
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| ○キーワード (推奨): | 1. | (英) Adenoma (日) (読)
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| 2. | (英) Carcinoma (日) (読)
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| 3. | (英) Colonic Polyps (日) (読)
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| 4. | (英) Colorectal Neoplasms (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Intestinal Polyposis (日) (読)
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| 7. | (英) Microsatellite Instability (日) (読)
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| 8. | (英) Mutation (日) (読)
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| 9. | (英) Proto-Oncogene Proteins B-raf (日) (読)
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| 10. | (英) Retrospective Studies (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Gastroenterology ([財団法人 日本消化器病学会])
(pISSN: 0944-1174, eISSN: 1435-5922)
| ○ISSN (任意): | □ | 1435-5922
ISSN: 0944-1174
(pISSN: 0944-1174, eISSN: 1435-5922) Title: Journal of gastroenterologyTitle(ISO): J GastroenterolSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 57
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 286 299
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2022年 4月 初日 (令和 4年 4月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s00535-022-01858-8 (→Scopusで検索)
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| ○PMID (任意): | □ | 35194694 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s00535-022-01858-8 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Adenoma-carcinoma pathway (日)
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| 4. | (英) KeywordList.Keyword: Colorectal cancer (日)
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| 5. | (英) KeywordList.Keyword: Serrated polyposis syndrome (日)
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| 6. | (英) KeywordList.Keyword: Serrated-neoplasia pathway (日)
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