| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
| [継承] |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kanemoto Yoshiaki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Hayakawa Akira (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Sawada Takahiro (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Amano Rei (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Kurokawa Tomohiro (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 沢津橋 俊 ([徳島大学.先端酵素学研究所.技術開発支援部門])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | 福本 誠二
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Mori Jinichi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | (英) Kato Shigeaki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Transcriptional Regulation of 25-Hydroxyvitamin D-24-Hydroxylase (CYP24A1) by Calcemic Factors in Keratinocytes. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) CYP24A1 regulates serum vitamin D (VD) levels by inactivating 25(OH)D, which is the precursor of the active form of VD [1 ,25(OH)D], and CYP24A1 expression is controlled by multiple calcemic factors such as 1 ,25(OH)D, calcium, and phosphate. A major phosphaturic factor, FGF23, has also been identified as a regulator of serum VD levels by affecting renal CYP24A1 gene expression; however, its effect on CYP24A1 in extrarenal cells remains largely unstudied. Therefore, the direct effect of FGF23 on CYP24A1 was examined in a human keratinocyte cell line (HaCaT). In this cell line, significant induction of CYP24A1 gene expression by 1 ,25(OH)D was seen within 4 h by qRT-PCR, and this was mediated by the VD receptor, as shown in a mutant cell line genetically deficient in this receptor. However, FGF23 treatment up to 12 h did not induce CYP24A1 expression, although the expected activation of the downstream MAPK signaling pathway was seen. High calcium and phosphate treatments were also ineffective in inducing CYP24A1 gene expression. Furthermore, a luciferase assay showed no activation of a VD-sensitive proximal CYP24A1 promoter in response to the calcium and phosphate treatments, suggesting that the effect of FGF23 on dermal CYP24A1 gene expression is indirect. From these findings, we speculate that CYP24A1 gene regulation by FGF23 occurs mainly in renal cells, but not in extrarenal cells, at least not in keratinocytes. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Calcitriol (日) (読)
| [継承] |
| 2. | (英) Humans (日) (読)
| [継承] |
| 3. | (英) Keratinocytes (日) (読)
| [継承] |
| 4. | (英) Receptors, Calcitriol (日) (読)
| [継承] |
| 5. | ビタミンD (vitamin D)
| [継承] |
| 6. | (英) Vitamin D3 24-Hydroxylase (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Nutritional Science and Vitaminology ([日本栄養·食糧学会]/[日本ビタミン学会])
(pISSN: 0301-4800, eISSN: 1881-7742)
| ○ISSN (任意): | □ | 1881-7742
ISSN: 0301-4800
(pISSN: 0301-4800, eISSN: 1881-7742) Title: Journal of nutritional science and vitaminologyTitle(ISO): J Nutr Sci Vitaminol (Tokyo)Supplier: 日本ビタミン学会Publisher: Center for Academic Publications Japan (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 67
| [継承] |
| ○号 (必須): | □ | 6
| [継承] |
| ○頁 (必須): | □ | 424 428
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2021年 0月 初日 (令和 3年 0月 初日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.3177/jnsv.67.424 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 34980721 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.3177/jnsv.67.424 (日)
| [継承] |
| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 3. | (英) KeywordList.Keyword: CYP24A1 (日)
| [継承] |
| 4. | (英) KeywordList.Keyword: FGF23 (日)
| [継承] |
| 5. | (英) KeywordList.Keyword: VDR (日)
| [継承] |
| 6. | (英) KeywordList.Keyword: transcription (日)
| [継承] |
| 7. | (英) KeywordList.Keyword: vitamin D (日)
| [継承] |