| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 島田 健司 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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| 2. | 山口 泉
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| 3. | 石原 学 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.救急集中治療医学])
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| 4. | 宮本 健志 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| 5. | 曽我部 周
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| 6. | 三宅 一央 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域脳神経医療学])
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| 7. | 多田 恵曜 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| 8. | (英) (日) 北里 慶子 (読) きたざと けいこ
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| 9. | 兼松 康久
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| 10. | 髙木 康志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| ○題名 (必須): | □ | (英) Involvement of Neutrophil Extracellular Traps in Cerebral Arteriovenous Malformations (日)
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| ○要約 (任意): | □ | (英) Cerebral arteriovenous malformations (cAVMs) represent tangles of abnormal vasculature without intervening capillaries. High-pressure vascular channels due to abnormal arterial and venous shunts can lead to rupture. Multiple pathways are involved in the pathobiology of cAVMs including inflammation and genetic factors such as KRAS mutations. Neutrophil release of nuclear chromatin, known as neutrophil extracellular traps (NETs), plays a multifunctional role in infection, inflammation, thrombosis, intracranial aneurysms, and tumor progression. However, the relationship between NETs and the pathobiology of cAVMs remains unknown. We tested whether NETs play a role in the pathobiology of cAVMs. We analyzed samples from patients who had undergone surgery for cAVM and immunohistochemically investigated expression of citrullinated histone H3 (CitH3) as a marker of NETs. CitH3 expression was compared among samples from cAVM patients, epilepsy patients, and normal human brain tissue. Expressions of thrombotic and inflammatory markers were also examined immunohistochemically in samples from cAVM patients. Expression of CitH3 derived from neutrophils was observed intravascularly in all cAVM samples but not other samples. Nidi of AVMs showed migration of many Iba-I-positive cells adjacent to the endothelium and endothelial COX2 expression, accompanied by expression of IL-6 and IL-8 in the endothelium and intravascular neutrophils. Unexpectedly, expression of CitH3 was not necessarily localized to the vascular wall and thrombus. Our results offer the first evidence of intravascular expression of NETs, which might be associated with vascular inflammation in cAVMs. (日)
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| ○誌名 (必須): | □ | World Neurosurgery (World Federation of Neurosurgical Societies)
(pISSN: 1878-8750, eISSN: 1878-8769)
| ○ISSN (任意): | □ | 1878-8769
ISSN: 1878-8750
(pISSN: 1878-8750, eISSN: 1878-8769) Title: World neurosurgeryTitle(ISO): World NeurosurgPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ |
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | E1 E7
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2021年 8月 31日 (令和 3年 8月 31日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.wneu.2021.08.118 (→Scopusで検索)
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| ○PMID (任意): | □ | 34478890 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-85115331132
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S1878-8750(21)01306-1 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.wneu.2021.08.118 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Cerebral arteriovenous malformation (日)
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| 5. | (英) KeywordList.Keyword: Citrullinated histone-H3 (日)
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| 6. | (英) KeywordList.Keyword: Neutrophil extracellular traps (日)
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