| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 髙士 祐一
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| 2. | 沢津橋 俊 ([徳島大学.先端酵素学研究所.技術開発支援部門])
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| 3. | 遠藤 逸朗 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.生体機能解析学])
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| 4. | (英) Ohnishi Yukiyo (日) (読)
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| 5. | 安倍 正博
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| 6. | 松久 宗英 ([徳島大学.先端酵素学研究所.基幹研究部門]/徳島大学病院アンチエイジングセンター センター長(併任))
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| 7. | (英) Kawanami Daiji (日) (読)
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| 8. | 松本 俊夫
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| 9. | 福本 誠二
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| ○題名 (必須): | □ | (英) Skeletal FGFR1 signaling is necessary for regulation of serum phosphate level by FGF23 and normal life span. (日)
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| ○要約 (任意): | □ | (英) Fibroblast growth factor (FGF) 23 produced by the bone is the principal hormone to regulate serum phosphate level. Serum FGF23 needs to be tightly regulated to maintain serum phosphate in a narrow range. Thus, we hypothesized that the bone has some phosphate-sensing mechanism to regulate the production of FGF23. Previously we showed that extracellular phosphate induces the phosphorylation of FGF receptor 1 (FGFR1) and FGFR1 signaling regulates the expression of , whose product works to increase FGF23 production . In this study, we show the significance of FGFR1 in the regulated FGF23 production and serum phosphate level . We generated late-osteoblast/osteocyte-specific -knockout mice ( ) by crossing the and the floxed mouse lines. We evaluated serum phosphate and FGF23 levels, the expression of in the bone, the body weight and life span. A selective ablation of aborted the increase of serum active full-length FGF23 and the enhanced expression of in the bone by a high phosphate diet. These mice showed more pronounced hyperphosphatemia compared with control mice. In addition, these mice fed with a control diet showed body weight loss after 23 weeks of age and shorter life span. These results reveal a novel significance of FGFR1 signaling in the phosphate metabolism and normal life span. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Biochemistry and Biophysics Reports (Elsevier B.V.)
(eISSN: 2405-5808)
| ○ISSN (任意): | □ | 2405-5808
ISSN: 2405-5808
(eISSN: 2405-5808) Title: Biochemistry and biophysics reportsTitle(ISO): Biochem Biophys RepPublisher: Elsevier BV (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 27
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 101107 101107
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2021年 8月 17日 (令和 3年 8月 17日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bbrep.2021.101107 (→Scopusで検索)
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| ○PMID (任意): | □ | 34458594 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.bbrep.2021.101107 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Fibroblast growth factor 23 (日)
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| 4. | (英) KeywordList.Keyword: Fibroblast growth factor receptor 1 (日)
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| 5. | (英) KeywordList.Keyword: Life span (日)
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| 6. | (英) KeywordList.Keyword: Phosphate (日)
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