| ○種別 (必須): | □ | 学術論文 (紀要その他)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 徳島大学以外での単独著作 (徳島大学以外での単一の研究グループ(研究室等)内の研究 (単著も含む))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 上杉 篤史 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔外科学])
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| 2. | (英) Tsushima Fumihiko (日) 津島 文彦 (読) つしま ふみひこ
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| 3. | (英) Kodama Makoto (日) 児玉 真 (読) こだま まこと
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| 4. | (英) Kuroshima Takeshi (日) 黒嶋 雄志 (読) くろしま たけし
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| 5. | (英) Sakurai Jinkyo (日) 櫻井 仁亨 (読) さくらい じんきょう
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| 6. | (英) Harada Hiroyuki (日) 原田 浩之 (読) はらだ ひろゆき
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| ○題名 (必須): | □ | (英) Oral granuloma in a pediatric patient with chronic graft-versus-host disease: a case report (日)
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| ○要約 (任意): | □ | (英) Oral mucositis is often observed with graft-versus-host disease (GVHD); however, the occurrence of oral granuloma is rare. The rapid increase in granulomatous lesions should be distinguished from malignant tumors in patients with GVHD because malignant diseases can develop in those patients. This case is the youngest pediatric patient with granuloma associated with GVHD. The patient was a 1-year and 5-mo-old girl who presented to our department for the management of oral nodules. At the age of 5 mo, she was diagnosed with primary immunodeficiency disease, cord blood transplant was performed at 11 mo and bone marrow transplant at 1 year of age. After transplantation, GVHD and oral mucositis developed, and tacrolimus was administered. Interestingly, nodules appeared on the lower lip and buccal mucosa, which spontaneously disappeared. Then, a new nodule appeared on the left lateral border of the tongue. Resection was performed and the histopathological diagnosis was granuloma. The origin of these nodules were considered to be the fibroblasts activated under inflammation caused by GVHD because the calcineurin inhibitor tacrolimus acted on their proliferation. It is very important to distinguish oral granulomatous lesions from malignancies if GVHD is present at the base and if immunosuppressive agents and steroids are being administered. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | World Journal of Clinical Cases (Baishideng Publishing Group Inc.)
(eISSN: 2307-8960)
| ○ISSN (任意): | □ | 2307-8960
ISSN: 2307-8960
(eISSN: 2307-8960) Title: World journal of clinical casesTitle(ISO): World J Clin CasesPublisher: Baishideng Publishing Group (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 8
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| ○号 (必須): | □ | 22
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| ○頁 (必須): | □ | 5663 5669
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2020年 11月 26日 (令和 2年 11月 26日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.12998/wjcc.v8.i22.5663 (→Scopusで検索)
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| ○PMID (任意): | □ | 33344558 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.12998/wjcc.v8.i22.5663 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Case Reports (日)
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| 3. | (英) KeywordList.Keyword: Bone marrow transplantation (日)
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| 4. | (英) KeywordList.Keyword: Case report (日)
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| 5. | (英) KeywordList.Keyword: Graft-versus-host disease (日)
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| 6. | (英) KeywordList.Keyword: Oral granuloma (日)
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| 7. | (英) KeywordList.Keyword: Primary immunodeficiency disease (日)
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| 8. | (英) KeywordList.Keyword: Tacrolimus (日)
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| 9. | (英) CoiStatement: Conflict-of-interest statement: The authors declare that they have no conflict of interest. (日)
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